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. 2016 May 11;5(7):459–471. doi: 10.1016/j.molmet.2016.05.003

Figure 1.

Figure 1

PI3K inhibition amplifies insulin secretion in mouse and human islets, but not in islets from T2D donors. A, Static GSIS was measured from mouse islets treated with DMSO (open bars) or wortmannin (100 nM) (black bars). B, GSIS was measured via perifusion of mouse islets treated with DMSO (0.1%) (open circle) or wortmannin (100 nM) (black circle). C, GLP-1 (100 nM)-amplified GSIS was measured from mouse islets treated with DMSO (open bars) or wortmannin (100 nM) (black bars). D, Forskolin (1 μM)-amplified GSIS was measured from mouse islets treated with DMSO (open bars) or wortmannin (100 nM) (black bars). E, shows the same as A, but in human islets from non-diabetic donors. F, Forskolin (100 nM)-amplified GSIS was measured from non-diabetic human islets treated with DMSO (open bars) or wortmannin (100 nM) (black bars). G, shows the same as E, but in human islets from T2D donors. *-p < 0.05, **-p < 0.01, ***-p < 0.001.