Figure 4.

Massive fatty liver affects liver lipid and glucose metabolism. (A) Gross abdominal morphology of 6-wk-old WT and IR^FKO male mice. (B) Representative liver images of 6- or 12-wk old WT and IR^FKO male mice. (C) Liver weights of 6- or 12-wk-old male or female WT or IR^FKO mice (n = 6–9). (D) Representative images from H&E liver sections of 6- or 12-wk-old male or female WT or IR^FKO mice. (E) Triglyceride (TG) content in livers from 6-wk-old male or female WT or IR^FKO mice (n = 5–7). (F) Lipogenesis and gluconeogenesis markers expression in liver from 6-wk-old male or female WT or IR^FKO mice (n = 5). All qPCR data are normalized to TBP and all quantitative data presented as mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001.