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. 2016 May 14;5(7):480–490. doi: 10.1016/j.molmet.2016.05.005

Figure 6.

Figure 6

Ablation of IR affects BAT functions and metabolism. (A) BAT weights and representative images of 6- or 12-wk-old male or female WT or IRFKO mice (n = 6–9). (B) Representative images of H&E BAT sections of 6-wk-old male WT or IRFKO mice. (C) Expression of differentiation markers in BAT from WT or IRFKO mice (n = 4–5). Expression of de novo lipogenesis (D), thermogenesis (E), and glycolysis (F) markers in BAT from 6-wk-old male or female WT or IRFKO mice (n = 5). (G) Expression of differentiation, thermogenesis, lipogenesis, and glycolysis markers in BAT from P0 WT or IRFKO mice (n = 3–5). (H) Western blot analysis of UCP1 protein from 8-wk-old and P0 WT or IRFKO BAT (n = 2). (I) Rectal temperature of 8-wk-old male mice measured during exposure to 4 °C (n = 6–7). All qPCR data are normalized to TBP and all quantitative data presented as mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001.