Table 2. Correlation analyses of subcutaneous and visceral adipose tissue HIF3A mRNA expression with metabolic parameters, methylation levels and mRNA expression of leptin and PPARG.

	HIF3AmRNA Expression in subcutaneous adipose tissue			HIF3A mRNA Expression in visceral adipose tissue
	r	p-value	adj. p-value	r	p-value	adj. p-value
Age (years)	−0.23	4.61 × 10−5	0.032	−0.237	3.08 × 10−5	0.076
BMI (kg/m2)	0.239	2.86 × 10−5	0.017a	0.283	5.46 × 10−7	8.84 × 10−4a
Body weight (kg)	0.235	5.56 × 10−5	0.467a	0.263	5.45 × 10−6	0.280a
Height (m)	0.044	0.458	0.467	0.001	0.983	0.538
Waist (cm)	0.472	8.41 × 10−9	0.010	0.515	1.89 × 10−10	0.048
Hip (cm)	0.387	2.13 × 10−5	0.425	0.442	6.73 × 10−7	0.628
WHR	0.172	0.067	0.018	0.139	0.135	0.033
Visceral fat area (cm2)	0.391	3.19 × 10−5	0.636	0.442	1.71 × 10−6	0.479
SC fat area (cm2)	0.392	2.99 × 10−5	0.240	0.465	4.06 × 10−7	0.604
CT ratio (sc/vis)	−0.259	7.04 × 10−3	0.165	−0.319	7.80 × 10−4	0.325
Body fat (%)	0.324	0.017	0.055a	0.442	8.23 × 10−4	0.013a
CRP (mg/dl)	−0.138	0.021	1.8 × 10−3	−0.153	0.010	3.19 × 10−4
Leucocytes/nl	−0.127	0.032	3.05 × 10−3	−0.133	0.024	1.13 × 10−3
Met Blood (%)	0.054	0.720	0.618	0.023	0.876	0.772
Met SAT (%)	−0.054	0.687	0.482	−0.088	0.498	0.345
Met VAT (%)	0.060	0.648	0.667	−0.045	0.729	0.757
Leptin mRNA sc	0.227	2.82 × 10−4	2.37 × 10−4	0.216	5.28 × 10−4	1.41 × 10−3
Leptin mRNA vis	0.117	0.063	0.043	0.195	2.0 × 10−3	2.60 × 10−3
PPARG mRNA sc	0.001	0.977	0.939	0.002	0.967	0.878
PPARG mRNA vis	0.050	0.253	0.439	0.111	0.010	0.023

r - correlation coefficient (Pearson adj. – p-value adjusted to age, sex and BMI), ^aadjusted for sex and age; BMI – Body Mass Index, WHR – waist-to-hip ratio, sc - subcutaneous, CRP – C-reactive protein, Met Blood (%)/Met SAT (%)/Met VAT (%) - Methylation of cg22891070 in HIF3A in blood/SAT/VAT.