Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Jun 27;6:28699. doi: 10.1038/srep28699

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

(a) Viral load in the brain was assessed by plaque assay in TMEV-infected mice treated with vehicle (VEH) or ritonavir (RIT) at 3 and 7 dpi. There was no difference between treatment groups at either timepoint. n = 5 mice per treatment and per timepoint. (b,c) Ritonavir (10 μg/mL) and the standard calpain inhibitor E64 (10 μg/mL) did not alter TMEV infectivity when added directly to cells during a plaque assay. Images are representative of the n = 6 samples per condition. (d,e) Dose response analysis for ritonavir added directly to cells during TMEV infection showed no effect on infectivity (d; number of plaques) or viral fitness (e; plaque size) even at very high concentrations. n = 6 samples per condition from two independent experiments. Graphs show means ± 95% confidence intervals.