Table 2. Predicted cross-sectional area of a 7 or 8 TMH region in various predicted oligomers.
| In silico model | TMH cross-sectional area for various oligomers (nm2) |
||||
|---|---|---|---|---|---|
| dimer | trimer | tetramer | pentamer | hexamer | |
| 8 TMH only | 28.7 | 41.9 | 47.2 | 65.2 | 82.1 |
| 7 TMH CESA (including the large central domain) | 30.4 | 44.4 | 49.4 | 62.1 | 88.0 |
The TMH cross sectional areas in various oligomers of two alternative computational models are shown. ‘8 TMH’ indicates a model including only eight alpha helical regions and short linkers between them. In contrast, ‘7 TMH CESA’ indicates a model inclusive of seven TMH and the large central cytosolic domain. These dimensions can be compared to the range of single lobe areas derived from original images or image averages: 37.6–42.0 nm2 (overall mean of 39.5 nm2; see Table 1).