Table 2. Univariate and multivariate Cox analysis of the overall survival.

Variable	Univariate analysis			Multivariate analysis
	HR	P value	95% CI	HR	P value	95% CI
RIOK2
Low vs. High	2.878	0.000**	1.852–4.474	2.105	0.003*	1.286–3.445
NOB1
Low vs. High	2.030	0.001*	1.327–3.104	1.858	0.005*	1.207–2.862
Gender
Male vs. Female	0.715	0.124	0.467–1.096
Age, yr
<60 vs. ≥60	1.099	0.662	0.719–1.681
Smoking status
No vs. Yes	1.054	0.807	0.691–1.607
Tumour diameter (cm)
<3 vs. ≥3	1.641	0.021*	1.078–2.502
TNM clinical stage
I and II vs. III	3.381	0.000**	2.191–5.216	2.166	0.002*	1.331–3.524
Lymph node metastasis
No vs. Yes	1.795	0.010*	1.148–2.806
Differentiation
Well vs. Moderately vs. Poorly	2.172	0.000**	1.436–3.286

HR, hazard ratio; CI, confidence interval. *P < 0.05, **P < 0.001.