Table 6. Estimates from a multiple linear regression model for age, adjusting for gender, race (all patients) tumor location, histology type among patients Stages I, II, III disease.

Age difference (years):Stages I,II,III (Tx/Nx/M0)	Adenocarcinoma n = 12381	Squamous cell carcinoma n = 22464
Adjusted mean
age(years),stage IA	68.25 (68.21~68.29)	71.46(71.42~71.50)
IB vs. IA	0.91(0.53~1.28), p < 0.001	0.24(−0.22~0.71), p = 0.307
IIA vs. IA	−0.06(−0.56~0.44), p = 0.813	0.75(0.21~1.15), p = 0.008
IIB vs. IA	−0.16(−0.68~0.35), p = 0.524	1.82(1.26~2.46), p < 0.001
IIIA vs. IA	0.38(−0.76~0.1), p = 0.057	1.64(1.23~2.12), p < 0.001
IIIB vs. IA	1.17(0.47~1.87), p = 0.001	2.52(1.90~3.10), p < 0.001
Adjusted mean
age(years),T1a	67.57(67.53~67.61)	70.96(70.94~71.01)
T1b vs. T1a	0.17(−0.28~0.63), p = 0.453	0.45(−0.19~1.10), p = 0.109
T2a vs. T1a	1.04(0.68~1.39), p = 0.036	−0.21(−0.76~0.27), p = 0.391
T2b vs. T1a	1.44(0.8~2.08), P < 0.001	−0.39(−1.00~0.21), p = 0.201
T3 vs. T1a	1.66(1.26~2.05), p < 0.001	0.57(0.32~1.12), p = 0.038
T4 vs. T1a	0.92(0.31~1.5), p = 0.003	1.82(1.21~2.46), p < 0.001
Adjusted mean
age(years),N0	68.60(68.54~68.66)	71.43(71.39~71.46)
N1 vs. N0	1.14(0.67~1.62), p < 0.001	1.89(1.03~2.76), p < 0.001
N2 vs. N0	1.08(0.69~1.48), p < 0.001	1.92(1.54~2.46), p < 0.001
N3 vs. N0	1.62(0.7~2.56), p = 0.001	3.01(2.49~3.53), p < 0.001

Values given are mean differences in ages by tumor size and stage of disease, with 95%CIs.