Table 2. Functional classification of miRNA candidates affected by DDX3 knockdown in HepG2 cells.
| Stem cell-like properties | microRNA | Target gene | PMID | Expression (shDDX3/shLuc) |
|---|---|---|---|---|
| Self-renewal | miR-200b | BMI1 | 21840484 | Down-regulation |
| miR-145 | SOX2 | 19409607 | Down-regulation | |
| KLF4 | 19409607 | |||
| c-MYC | 19202026 | |||
| NANOG | 21092188 | |||
| OCT4 | 24240684 | |||
| miR-204 | SOX4 | 23204299 | Down-regulation | |
| miR-33b | SALL4 | 25919570 | Down-regulation | |
| miR-1246 | CCNG2 | 25117811 | Up-regulation | |
| Differentiation | let-7e | WNT1 | 19398721 | Down-regulation |
| miR-200b | WNT1 | 23851184 | Down-regulation | |
| miR-1275 | CLDN11 | 22736761 | Down-regulation | |
| miR-181a/b/c/d | GATA6 | 19585654 | Up-regulation | |
| CDX2 | 19585654 | |||
| miR-92b | C/EBPβ | 23936298 | Up-regulation | |
| miR-27a | ZBTB10 | 23752185 | Up-regulation | |
| Chemoresistance | miR-30e | ABL | 25305453 | Down-regulation |
| miR-1246 | CCNG2 | 25117811 | Up-regulation | |
| Motility/EMT/invasion | miR-200b | ZEB1 | 24691972 | Down-regulation |
| miR-483 | CKB | 25601461 | Down-regulation | |
| miR-204 | EPHB2 | 23204299 | Down-regulation | |
| miR-145 | HMGA2 | 25444913 | Down-regulation | |
| miR-33b | HMGA2 | 25919570 | Down-regulation | |
| TWIST1 | 25919570 | |||
| miR-30a | MTDH | 23851509 | Up-regulation |