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. 2016 Jun 1;5(1):159–170. doi: 10.1089/biores.2016.0018

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© Justine Tanjaya et al. 2016; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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FIG. 3. — (A) Representative live micro-PET/CT images of NELL-PEG-treated group revealed a higher uptake of ¹⁸F-NaF ion over time, which corresponds to increased bone turnover rate in the targeted bone tissues, particularly the proximal humeri, vertebral body, distal femur, and proximal tibia compared with the PBS control group. ROIs were drawn at the distal femur–proximal tibia region and the lower lumbar region to encompass the areas that show high signal intensity. (B, C) Quantification of mean value at the distal femur–proximal tibia region and lower lumbar region (%ID/cc) at the fourth week postinjection. NELL-PEG-treated group exhibited significantly greater concentration of ¹⁸F-NaF ion uptake compared with the PBS control group. *Significant difference (p < 0.05) compared with the control group. Error bars represent standard error of the mean. Micro-PET/CT, micro-positron emission tomography/computed tomography; ROIs, regions of interest.