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. 2016 Jun 1;5(1):159–170. doi: 10.1089/biores.2016.0018

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© Justine Tanjaya et al. 2016; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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FIG. 5. — Histological analyses of distal femoral metaphysis in NELL-PEG-treated group and control. (A, B) H&E staining (bar, 200 μm) and (C, D) trichrome staining (bar, 200 μm) at the growth plate region show more trabecular bone formation in the NELL-PEG group compared with the PBS control. (E, F) High power view of OCN staining (bar, 50 μm) shows more osteoblasts in treated group (shown with arrows). (G, H) TRAP staining (bar, 50 μm) reveals more osteoclasts in the control group compared with the NELL-PEG injection group. (I–L) Quantification of bone remodeling process parameters that include osteocalcin+bone-lining cells per bone perimeter (OCN+cells/Bpm, mm⁻¹) and surface (Ob.S/Bs, %), TRAP+bone-lining cells per bone perimeter (TRAP+cells/Bpm, mm⁻¹), and surface (Oc.S/Bs, %). **Significant difference (p < 0.01) compared with the control group. Error bars represent standard error of the mean. H&E, hematoxylin and eosin; TRAP, tartrate-resistant acid phosphatase.