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. 2016 May 4;5(7):552–565. doi: 10.1016/j.molmet.2016.04.008

Figure 6.

Figure 6

DSAP lesion alters neuronal and transcriptional responses to Ex-4 in the PVH. PVH c-Fos activation in the SAP-Veh (A), SAP-Ex-4 (B), DSAP-Veh (C), and DSAP-Ex-4 (D). (E) C-Fos positive cell counts in the PVHm. Ex-4 increased c-Fos activation in the SAP (p < 0.05, 2-way ANOVA), but not in the DSAP group. (F) C-Fos positive cell counts in the PVHp. Ex-4 increased c-Fos activation in the SAP (p < 0.05, 2-way ANOVA) but not in the DSAP group. No change was observed for TRH (G) and Oxytocin (I) mRNA expression, but CRH mRNA expression (H) was decreased in the DSAP group after Ex-4 (p < 0.01, 2-way ANOVA). Data are means ± SEM. Different letters indicate a significant difference between the treatment groups after post-hoc Bonferroni-corrected comparisons (p < 0.05). PVHm: paraventricular nucleus, magnocellular, PVHp: paraventricular nucleus, parvocellular. TRH: thyrotropin-releasing hormone, CRH: corticotropin-releasing hormone. 10× bright field images. Scale bars = 100 μm.