Table 1.

Immunohistochemical Tumor Markers of Diagnostic Importance

Antigen	Tumor Type
Alpha-fetoprotein	Germ cell tumor, trophoblastic tumors, hepatocellular carcinoma.
Carcinoembryonic antigen	GIT, pancreas, cervix, uterus lung, breast.
Chromogranin	Neuroendocrine tumors
Cytokeratin	Carcinomas and sarcomas
Desmin	Sarcomas (smooth or skeletal muscle)
Epithelial membrane antigen(EMA)	Sarcomas and carcinomas
Glial filiary acid protein (GFAP)	Astrocytoma, ependymoma and giomas
HMB-45	Melanoma, nerve sheath tumors
Human chorionic gonadotropin (hCG)	Trophoblastic, germ cell tumors
Leukocyte common antigen (LCA, CD 45)	Lymphomas, leukemias, histiocytic tumors
Prostate specific antigen (PSA)	Prostate
Vimentin	Sarcomas; renal cel carcinoma; melanoma
Thyrolobulin	Thyroid(except medullary)
Smooth muscle actin (SMA)	GIST, leiomyosarcoma, mesothelioma
Plancental alkaline phosphatase (PLAP)	Trophoblastic tumors, testis, dysgerminoma