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. Author manuscript; available in PMC: 2016 Jun 27.
Published in final edited form as: Cytometry B Clin Cytom. 2013 Sep 16;86(6):383–396. doi: 10.1002/cyto.b.21125

Figure 4. Low Risk MDS BM samples versus Age-Matched Healthy BM samples.

Figure 4

Figure 4

Figure 4

A. Response of MDS BM samples to EPO or GCSF modulation Plots of EPO induced p-STAT5 levels in total nRBC, early erythroid and normoblasts (left) and GCSF induced p-STAT1, p-STAT3 and p-STAT5 levels in myeloid cells using the Uu metric (right).

B. MDS Samples with Increase Myeloid Frequency have Increased STAT Activation Flow cytometry dot plots measuring p-STAT5 (X-axis) versus p-STAT3 (Y axis) in response to GCSF in MDS samples with a higher percentage of myeloid elements (lower panels), same percentage (middle panels) and a lower percentage of myeloid elements (upper panel) compared to healthy age-matched control myeloid samples.

C. GCSF Modulated STAT Activation in Healthy Older BM Samples. Flow cytometry dot plots measuring p-STAT5 (X-axis) versus p-STAT3 (Y axis) in response to GCSF in healthy age-matched control myeloid samples.