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. 2016 Jun 27;6:28633. doi: 10.1038/srep28633

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Venn diagram illustrates the number of aging-related genes generated from comparison between WT mice at different ages. Livers from 3 individual mice were used for microarray analysis for each set of samples. Gene expression from WT mice at 3, 12, and 19 months (Mon) of age were compared. Genes within the intersection of the 2 circles were defined as hepatic aging-related genes. (b) Venn diagram illustrates the number of Sirt1-dependent aging-related genes. Livers from 3 individual mice were used for microarray analysis for each set of samples. Gene expression from WT and MT mice at 3 months (Mon) of age was compared with each other, as well as with aging-related genes identified in (a). Genes within the intersection of the 2 circles were defined as Sirt1-dependent aging-related genes. (c,d) Representative validation results using qRT-PCR of up-regulated (c) and down-regulated (d) Sirt1-dependent aging-related genes. The level of gene expression for 3-month-old WT mice was set as 1. Data represent the mean ± SD (n = 3). *p < 0.05 when compared with WT 3-month-old samples.