Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Jun 27;6:28633. doi: 10.1038/srep28633

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

Sirt1 is involved in many biological processes through affecting protein acetylation dynamics, thus, promotes longevity. By deacetylating histone H4 K16 on Per2 promoter, Sirt1 downregulates Per2 expression. In return, Per2 inhibits Sirt1 expression by shutting down Clock/Bmal1 activation on Sirt1 promoter. Per2, as an important negative regulator in Circadian, its upregulation causes premature aging. Hence, losing the balance of reciprocal inhibitory relationship between Sirt1 and Per2 is a major step that leads to dysregulation of Sirt1 dependent aging progress.