Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The evolution of CARs. Early CARs were molecules composed of ectodomains from immunoglobulin VH or VL or from various receptors, fused with the TCR α or β chain. Modern CARs are composed of an extracellular antigen-binding domain usually derived from an immunoglobulin scFv, an extracellular spacer or ‘hinge’, a transmembrane domain and various ICDs required for T-cell activation.
