Table 6.

DNA methylation of MR-identified CpGs was associated with gene expression of genes involved in lipid metabolism

		Chr	Position	Mean DNAm (%)	Gene	Estimate (logCPM/β)a	P value	Chromatin state
TG	cg00574958	11	68,607,623	12	CPT1A	−3.3 (−4.1,−2.5)	1.5 × 10−14	Flanking active TSS
	cg17058475	11	68,607,738	14	CPT1A	−1.7 (−2.3,−1.1)	1.8 × 10−8	Enhancer
	cg11024682	17	17,730,095	26	SREBF1	−2.4 (−2.8,−2.0)	5.2 × 10−33	Enhancer
LDL-C	cg27168858	1	55,351,660	78	DHCR24	−4.1 (−4.9,−3.3)	2.4 × 10−25	Flanking active TSS
HDL-C	cg27243685	21	43,642,367	83	ABCG1	−4.5 (−5.4,−3.6)	4.0 × 10−24	Flanking active TSS
	cg06500161	21	43,656,588	60	ABCG1	−5.1 (−5.7,−4.5)	1.2 × 10−56	Weak transcription

CpGs are located in regions of active gene regulation

^a Estimate is the log counts per million change in gene expression per β (0–1) change in DNA methylation

DNAm DNA methylation