TABLE 3.
Clinical outcomes preimplementation and postimplementation of microarray-based identification of Gram-negative organisms from blood culture broths using BC-GN
| Clinical outcome | Pre-BC-GN | Post-BC-GN | P value |
|---|---|---|---|
| Mean time from initial Gram stain to BC-GN identification, h | NAa | 3.5 | NA |
| Mean time from initial Gram stain to organism identification, h | 37.9 | 10.9 | <0.001b |
| Mean time from initial Gram stain to effective therapy, h | |||
| All cases | 10.2 | 6.5 | 0.12b |
| Cases on suboptimal empirical therapy | 30.3 | 19.1 | 0.12b |
| No. of cases in which therapy was de-escalated | 33 | 37 | 0.66c |
| Mean time from initial Gram stain to de-escalation, h | 40.9 | 34.1 | 0.14b |
| Recurrence of bacteremia, no. (%) | 8 (8.2) | 3 (3.1) | 0.21c |
| Mean total length of stay in hospital, days | 15.2 | 18.0 | 0.52b |
| Mean length of hospital stay after positive culture, days | 9.7 | 9.4 | 0.87b |
| Mean length of stay in ICU, days | 16.2 | 12.0 | 0.03b |
| 30-day mortality, no. (%) | 19 (19.2) | 8 (8.1) | 0.04c |
| ESBL cases, no. | 15 | 11 | 0.53c |
| Length of stay in hospital, days | 12.0 | 13.5 | 0.59b |
| Mean time to effective therapy, h (no.)d | 41.4 (9) | 7.3 (9) | 0.04b |
| 30-day mortality, no. (%) | 4 (26.7) | 0 (0) | 0.11c |
a
NA, not applicable.
b
The Mann-Whitney U test was performed.
c
The Fisher exact test was performed.
d
This category excludes cases that never received adequate antimicrobial coverage (n = 2, pre-BC-GN group only) and cases already on adequate empirical therapy.