Multiple-infection subjects. Data are shown for 37 subjects identified as having multiple infection. The line represents a longitudinal time scale from incident infection to the last sampling point in months. The color symbol designates the subtype; first, second, and third infections with the same subtype are represented with circles, triangle, and squares, respectively. Time points representing subjects with viremia from whom a sequence was unobtainable are designated in black, time points representing subjects from whom E1/HVR1 was unable to be amplified are designated with an asterisk, and time points representing RNA-negative results are represented by an empty diamond with a black outline. Time points where two viral strains were present have two symbols indicated (see key).