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. 2016 Jun 27;7:254. doi: 10.3389/fimmu.2016.00254

Figure 1.

Figure 1

Amigo2 is upregulated more specifically in RA synoviocytes in inflammatory conditions. Synoviocytes were exposed to IL-17A or TNF-α alone or to a combination of both for 12 h. Amigo2 and Amigo3 expressions were assessed by transcriptomic analysis (A,B) and Amigo2 expression was also assessed by quantitative real-time PCR (C,D). Gene expression was compared between the different treatments and is represented as fold changes compared to control in RA synoviocytes (A–C). Amigo2 expression was also evaluated in synoviocytes from different clinical settings (healthy, OA and RA) and is expressed as fold changes compared to healthy synoviocytes exposed to vehicle (D). Data are the mean of at least three independent experiments ± SEM. #Comparison with control situation, *comparison between different cytokine combinations (C) or between cell types (D). *P ≤ 0.05, **P ≤ 0.01, ***, ###P ≤ 0.001.