Table 1. Adjusted and Unadjusted Odds Ratio of Studies Assessing the Association Between XRCC1 Arg194Trp Polymorphism and Breast Cancer.
| References | Menopausal Status | Trp/Trp Versus Arg/Arga | Arg/Trp Versus Arg/Arga | Trp/Trp and Arg/Trp Versus Arg/Arga | |||
|---|---|---|---|---|---|---|---|
| Adjusted OR (95% CI) | Unadjusted OR (95% CI) | Adjusted OR (95% CI) | Unadjusted OR (95% CI) | Adjusted OR (95% CI) | Unadjusted OR (95% CI) | ||
| Duell E. J. (2001) (African-Americans) (47) | Mix | - | NCb | - | 0.64 (0.28 - 1.42)b | 0.70 (0.30 - 1.50) | - |
| Duell E. J. (2001) (White) (47) | Mix | - | NCb | - | 0.75 (0.40 - 1.39)b | 0.70 (0.40 - 1.30) | - |
| Kim S. U. (2002) (57) | |||||||
| Mix | 0.90 (0.48 - 1.67) | - | 1.10 (0.76 - 1.73) | - | - | 1.08 (0.71 - 1.62)b | |
| Pre | 1.30 (0.57 - 2.95) | - | 1.30 (0.74 - 2.18) | - | - | 1.27 (0.74 - 2.18)b | |
| Post | 0.50 (0.17 - 1.32) | - | 1.00 (0.50 - 1.86) | - | - | 0.83 (0.42 - 1.62)b | |
| Han J. (2003) (51) | Mix | - | 1.33 (0.17 - 10.00)b | - | 0.79 (0.61 - 1.03)b | 0.79 (0.60 - 1.04) | 0.81 (0.62 - 1.05) |
| Moullan N. (2003) (67) | Mix | 1.61 (0.10 - 26.10) | - | 0.95 (0.56 - 1.61) | - | - | 1.02 (0.61 - 1.71)b |
| Smith T. R. (2003) (84) | Mix | NC | - | 1.47 (0.80 - 2.70) | - | 1.60 (0.89 - 2.87) | - |
| Smith T. R. (2003) (22) | Mix | - | NCb | - | 1.10 (0.58 - 2.02)b | - | 1.12 (0.60 - 2.03)b |
| Deligezer U. (2004) (45) | Mix | - | NC | - | 0.41 (0.16 - 1.06) | - | 0.47 (0.19 - 1.17) |
| Forsti A. (2004) (50) | Mix | - | NC | - | 1.27 (0.58 - 2.78) | - | - |
| Chacko P. (2005) (28) | |||||||
| Mix | 2.78 (0.82 - 9.40) | 2.73 (0.81 - 9.20) | 1.89 (0.99 - 3.62) | 1.85 (1.01 - 3.38) | 2.04 (1.12 - 3.72) | 1.98 (1.13 - 3.48) | |
| Pre | - | - | - | - | 1.35 (0.55 - 3.25) | - | |
| Post | - | - | - | - | 2.75 (1.28 - 5.90) | - | |
| Patel A. V. (2005) (69) | Post | - | - | - | - | 0.62 (0.40 - 0.95) | 0.66 (0.45 - 0.97) |
| Shen J. (2005) (81) | |||||||
| Mix | - | - | - | - | 0.93 (0.72 - 1.21) | - | |
| Pre | - | - | - | - | 0.78 (0.50 - 1.20) | - | |
| Post | - | - | - | - | 1.00 (0.72 - 1.38) | - | |
| Brewster A. M. (2006) (41) | Mix | - | NCb | - | 1.69 (0.99 - 2.87)b | 1.20 (0.72 - 2.00) | 1.12 (0.69 - 1.83) |
| Pachkowski B. F. (African-Americans) (2006) (68) | Mix | 0.70 (0.10 - 4.40) | - | 1.00 (0.70 - 1.30) | - | 1.00 (0.70 - 1.30) | - |
| Pachkowski B. F. (Whites) (2006) (68) | Mix | 0.90 (0.30 - 2.80) | - | 0.90 (0.70 - 1.20) | - | 0.90 (0.70 - 1.20) | - |
| Thyagarajan B. (2006) (23) | Mix | 0.98 (0.21 - 4.63) | 1.02 (0.23 - 4.57) | 1.23 (0.21 - 4.63) | 1.20 (0.77 - 1.87) | 1.21 (0.78 - 1.88) | 1.18 (0.77 - 1.81) |
| Zhang Y. (2006) (27) | |||||||
| Mix | 0.50 (0.20 - 1.40) | - | 0.90 (0.80 - 1.20) | - | - | 0.92 (0.73 - 1.15)b | |
| Pre | 0.60 (0.00 - 10.30) | - | 1.20 (0.80 - 1.80) | - | - | 1.19 (0.81 - 1.77)b | |
| Post | 0.50 (0.20 - 1.40) | - | 0.80 (0.60 - 1.00) | - | - | 0.75 (0.55 - 1.02)b | |
| Silva S. N. (2007) (21) | |||||||
| Mix | 1.65 (0.10 - 27.43) | 2.00 (0.12 - 32.14) | 1.48 (0.95 - 2.32) | 1.46 (0.94 - 2.26) | 1.49 (0.95 - 2.31) | 1.47 (0.95 - 2.27) | |
| Pre | NC | 0.05 (0.00 - 4.04) | 0.78 (0.16 - 3.68) | 0.83 (0.18 - 3.69) | 0.78 (0.16 - 3.68) | 0.81 (0.18 - 3.63) | |
| Post | - | - | - | - | - | - | |
| Loizidou M. A. (2008) (60) | Mix | - | 0.95 (0.36 - 2.46) | - | 1.02 (0.82 - 1.28) | - | 1.02 (0.81 - 1.28)b |
| Mitra A. K. (2008) (66) | Mix | - | 0.41 (0.08 - 2.08) | - | 0.35 (0.18 - 0.65) | - | 0.35 (0.19 - 0.64) |
| Sangrajrang S. (2008) (29) | |||||||
| Mix | 0.70 (0.42 - 1.14) | 0.75 (0.47 - 1.20) | 1.08 (0.81 - 1.44) | 1.08 (0.82 - 1.41) | 1.01 ( 0.77 - 1.32)b | ||
| Pre | 0.88 (0.45 - 1.73) | - | 1.23 (0.83 - 1.82) | - | - | 1.15 (0.80 - 1.65)b | |
| Post | 0.55 (0.26 - 1.16) | - | 0.92 (0.60 - 1.42) | - | - | 0.85 (0.56 - 1.28)b | |
| Smith T. R. (Caucasian) (2008) (83) | Mix | 8.74 (0.97 - 78.23) | - | 1.21 (0.74 - 1.97) | - | - | 1.34 (0.82 - 2.18)b |
| Smith T. R. (African-American) (2008) (83) | Mix | NC | - | 0.44 (0.12 - 1.67) | - | - | 0.82 (0.23 - 2.73)b |
| Sobczuk A. (2009) (37) | Post | - | 0.71 (0.33 - 1.54)b | - | 0.74 (0.36 - 1.50)b | - | 0.73 (0.37 - 1.41)b |
| Ming-Shiean H. (2010) (65) | Mix | 1.37 (0.87 - 2.17) | 1.36 (0.88 - 2.14) | 1.12 (0.84 - 1.47) | 1.09 (0.83 - 1.44) | 1.20 (0.87 - 1.62) | 1.17 (0.89 - 1.53)b |
| Sterpone S. (2010) (38) | Mix | - | NC | - | 1.82 (0.43 - 7.66) | - | - |
| Zipprich J. (2010) (89) | Mix | - | - | - | - | 1.17 (0.61 - 2.25) | - |
| Liu L. (2011) (59) | Mix | 1.16 (0.84 - 1.59) | - | 1.19 (0.99 - 1.44) | - | 1.19 (0.99 - 1.41) | - |
| Al Mutairi F. M. (2013) (39) | Mix | - | NC | - | 4.57 (1.47 - 14.21) | - | 4.57 (1.47 - 14.21) |
| Przybylowska-Sygut K. (2013) (70) | Mix | - | NC | - | 1.91 (1.15 - 3.14) | - | 1.94 (1.15 - 3.32)b |
| Ding P. (2014) (46) | Mix | - | 0.99 (0.66 - 1.48)b | - | 0.93 (0.73 - 1.18)b | 0.94 (0.75 - 1.18) | 0.94 (0.74 - 1.18)b |
| McCullough L. E. (2014) (63) | Post | - | - | - | - | - | 0.91 (0.62 - 1.32)b |
| Ramadan R. A. (2014) (71) | Mix | 3.76 (1.07 - 13.17) | 3.87 (1.24 - 12.05) | 4.42 (2.08 - 9.41) | 4.59 (2.33 - 9.06) | 4.28 (2.11 - 8.70) | 4.45 (2.35 - 8.45) |
| Smolarz B. (2014) (85) | Mix | - | 0.89 (0.34 - 2.28) | - | 0.59 (0.26 - 1.35) | - | 0.68 (0.29 - 1.57)b |
| Macias-Gomez, N. M. (2015) (62) | Mix | - | 1.41 (0.64 - 3.14) | - | 1.01 (0.71 - 1.44) | - | 1.06 (0.76 - 1.48) |
Abbreviations: CI, confidence interval; NC, not calculable; OR, odds ratio.
aReferences category for calculation of odds ratio.
bORs calculated by authors via Stata software (version 13).