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. 2016 Feb 23;9(1):e3467. doi: 10.17795/ijcp-3467

Table 3. Adjusted and Unadjusted Odds Ratio of Studies Assessing the Association Between XRCC1 Arg399Gln Polymorphism and Breast Cancer.

References Menopausal Status Gln/Gln Versus Arg/Arga Arg/Gln Versus Arg/Arga Gln/Gln and Arg/Gln Versus Arg/Arga
Adjusted OR (95% CI) Unadjusted OR (95% CI) Adjusted OR (95% CI) Unadjusted OR (95% CI) Adjusted OR (95% CI) Unadjusted OR (95% CI)
Duell E. J. (African-Americans) (2001) (47) Mix - 2.11 (0.52 - 9.99)b - 1.54 (1.03 - 2.32)b 1.70 (1.10 - 2.40) -
Duell E. J. (Whites) (2001) (47) Mix - 0.84 (0.52 - 1.33)b - 1.12 (0.81 - 1.54)b 1.00 (0.80 - 1.40) -
Kim S. U. (2002) (57) Mix 2.40 (1.20 - 4.72) 0.80 (0.51–1.16) 0.96 (0.63 - 1.44)b
Pre 3.80 (1.44 - 10.30) 1.20 (0.72–2.10) 1.51 (0.87 - 2.60)b
Post 1.40 (0.50 - 3.91) 0.40 (0.19–0.74) 0.50 (0.25 - 0.98)b
Han J. (2003) (51) Mix 1.03 (0.77 - 1.37) 1.06 (0.81 - 1.39) 1.07 (0.88–1.30) 1.06 (0.88 - 1.27) - 1.04 (0.88 - 1.24)b
Moullan N. (2003) (67) Mix 1.00 (0.57 - 1.76) - 0.96 (0.66–1.40) - - 0.91 (0.64 - 1.29)b
Shu X. O. (2003) (82) Mix 1.20 (0.85 - 1.69) 1.22 (0.87 - 1.71) 0.90 (0.76–1.08) 0.92 (0.77 - 1.09) 1.00 (0.84 - 1.18)b
Pre 1.19 (0.78 - 1.80) 1.20 (0.79 - 1.81) 0.79 (0.63–0.98) 0.79 (0.63 - 0.98) 0.90 (0.73 - 1.10)b
post 1.13 (0.61 - 2.11) 1.19 (0.65 - 2.17) 1.19 (0.87–1.62) 1.21 (0.90 - 1.64) 1.20 (0.90 - 1.62)b
Smith T. R. (2003) (84) Mix 1.07 (0.58 - 1.96) - 1.02 (0.70–1.51) - 1.03 (0.71 - 1.49) -
Smith T. R. (2003) (22) Mix - 1.09 (0.54 - 2.16)b - 0.81 (0.53 - 1.25)b - 0.86 (0.57 - 1.29)b
Deligezer U. (2004) (45) Mix - 1.26 (0.61 - 2.61) - 0.88 (0.53 - 1.47) - 0.96 (0.59 - 1.56)
Figueiredo J. C. (2004) (49) Mix 0.88 (0.57 - 1.37) 0.92 (0.60 - 1.41) 0.91 (0.67-1.23) 0.92 (0.68 - 1.24) - 0.92 (0.68 - 1.23)b
Forsti A. (2004) (50) Mix - 0.89 (0.46 - 1.72) - 1.10 (0.75 - 1.61) - 1.06 (0.73 - 1.52)b
Huang C. S. (2004) (52) Mix 1.92 (0.79 - 4.69)b 0.99 (0.61 - 1.60)b 1.11 (0.71 - 1.75)b
Chacko P. (2005) (28) Mix 2.69 (1.10 - 6.57) 2.66 (1.10 - 6.40) 2.04 (1.16-3.58) 2.02 (1.16 - 3.49) 2.18 (1.30 - 3.66) 2.14 (1.29 - 3.58)
Pre 6.32 (2.90 - 13.73)
Post 0.46 (0.36 - 1.57)
Dufloth R. M. (2005) (48) Mix - 0.89 (0.26 - 2.85)b - 0.84 (0.45 - 1.58)b - 0.85 (0.47 - 1.54)b
Metsola K. (2005) (64) Mix 1.39 (0.84 - 2.29) - 1.24 (0.93–1.65) - 1.26 (0.96 - 1.66) -
Patel A. V. (2005) (69) Post 1.27 (0.79 - 2.02) 1.08 (0.71 - 1.63) 1.01 (0.73–1.39) 0.95 (0.71 - 1.27) 1.06 (0.78 - 1.44) 0.98 (0.75 - 1.28)
Shen J. (2005) (81) Mix 0.97 (0.73 - 1.29) 1.08 (0.90-1.29) 1.06 (0.89 - 1.26)
Pre 1.03 (0.62 - 1.70) 1.28 (0.93-1.75) 1.23 (0.91 - 1.66)
Post 1.01 (0.71 - 1.44) 0.99 (0.79-1.24) 0.99 (0.80 - 1.24)
Brewster A. M. (2006) (41) Mix 1.22 (0.73 - 2.06) 1.11 (0.67 - 1.83) 1.64 (1.00–2.69) 1.48 (0.92 - 2.38) - 1.24 (0.88 - 1.75)b
Bu D. (2006) (42) Mix - 1.10 (0.48 - 2.53) - 0.98 (0.58 - 1.65) - 1.00 (0.58 - 1.69)b
Pachkowski B. F. (African-Americans) (2006) (68) Mix 1.80 (0.80 - 3.80) - 1.10 (0.90-1.50) - 1.20 (0.80 - 1.50) -
Pachkowski B. F. (Whites) (2006) (68) Mix 1.00 (0.80 - 1.30) - 1.10 (0.90-1.30) - 1.10 (0.90 - 1.30) -
Thyagarajan B. (2006) (23) Mix 0.91 (0.48 - 1.72) 0.91 (0.49 - 1.70) 1.29 (0.84–1.97) 1.29 (0.85 - 1.95) 1.20 (0.80 - 1.79) 1.19 (0.80 - 1.77)
Zhai X. (2006) (88) Mix 1.01 (0.60 - 1.70) 0.79 (0.57-1.08) 0.82 (0.61 - 1.11)
Pre 0.83 (0.55 - 1.28)
Post 0.82 (0.54 - 1.25)
Zhang Y. (USA) (2006) (27) Mix 0.90 (0.80 - 1.10) 1.10 (0.90-1.20) 1.03 (0.92 - 1.15)b
Pre 0.80 (0.60 - 1.10) 1.00 (0.80-1.20) 0.92 (0.77 - 1.11)b
Post 1.10 (0.80 - 1.30) 1.10 (0.90-1.30) 1.09 (0.95 - 1.26)b
Zhang Y. (Poland) (2006) (27) Mix 1.10 (0.90 - 1.40) 1.10 (1.00-1.30) 1.10 (0.97 - 1.25)b
Pre 1.00 (0.70 - 1.50) 1.20 (0.90-1.50) 1.12 (0.88 - 1.44)b
Post 1.10 (0.80 - 1.30) 1.10 (0.90-1.30) 1.08 (0.92 - 1.25)b
Costa S. (2007) (44) Mix 0.95 (0.57 - 1.53)b 0.65 (0.47 - 0.90)b 1.64 (1.22 - 2.21)b
Silva S. N. (2007) (21) Mix 0.87 (0.50 - 1.49) 0.80 (0.47 - 1.36) 0.87 (0.62–1.22) 0.83 (0.60 - 1.16) 0.87 (0.63 - 1.20) 0.83 (0.60 - 1.13)
Pre 0.52 (0.14 - 2.61) 0.65 (0.14 - 3.04) 0.49 (0.17–1.42) 0.49 (0.17 - 1.35) 0.50 (0.18 - 1.32) 0.52 (0.20 - 1.32)
Post
Ali M. F. (2008) (40) Mix - 3.54 (0.69 - 10.65)b - 1.52 (0.51 - 4.59)b - 2.05 (0.76 - 5.61)b
Kipikasova L. (2008) (58) Mix - 0.95 (0.39 - 2.27)b - 1.25 (0.68 - 2.29)b - 1.17 (0.67 - 2.04)b
Loizidou M. A. (2008) (60) Mix - 0.90 (0.68 - 1.18) - 0.95 (0.80 - 1.14 ) - 0.94 (0.79 - 1.11)b
Mitra A. K. (2008) (66) Mix - 2.91 (1.66 - 5.10) - 0.91 (0.56 - 1.50) - 1.41 (0.90 - 2.19)
Saadat M. (2008) (77) Mix 1.80 (0.90 - 3.61) 2.01 (1.02 - 3.94) 0.76 (0.47–1.20) 0.76 (0.49 - 1.18) 0.93 (0.61 - 1.44) 0.95 (0.63 - 1.42)
Pre 1.93 (0.81 - 4.62) 1.87 (0.81 - 4.37) 0.88 (0.46–1.67) 0.84 (0.45 - 1.56) 1.09 (0.61 - 1.96) 1.06 (0.60 - 1.85)
Post 1.20 (0.23 - 6.07) 1.03 (0.21 - 5.05) 0.48 (0.18–1.31) 0.46 (0.17 - 1.21) 0.57 (0.22 - 1.48) 0.53 (0.21 - 1.34)
Sangrajrang S. (2008) (29) Mix 1.80 (0.99 - 3.29) 1.74 (0.99 - 3.10) 1.20 (0.90–1.60) 1.17 (0.89 - 1.53) 1.23 (0.94 - 1.61)b1.09
Pre 1.45 (0.60 - 3.52) 1.05 (0.71–1.55) (0.75 - 1.57)b
Post 1.84 (0.79 - 4.28) 1.30 (0.84–2.00) 1.40 (0.93 - 2.11)b
Smith T. R. (Caucasian) (2008) (83) Mix 0.93 (0.56 - 1.54) - 1.01 (0.74-1.40) - 1.00 (0.73 - 1.35) 1.03 (0.75 - 1.40)b
Smith T. R. (African-American) (2008) (83) Mix 2.19 (0.09 - 52.25) - 1.13 (0.44-2.91) - 1.18 (0.47 - 2.96) 1.33 (0.53 - 3.29)b
Sobczuk A. (2009) (37) Post - 0.89 (0.42 - 1.84)b - 1.09 (0.54 - 2.18)b - 0.99 (0.52 - 1.88)b
Syamala V. S. (2009) (86) Mix - 1.58 (0.99-2.52)b - 1.60 (1.15 - 2.23)b - 1.59 (1.17 - 2.16)b
Jakubowska A. (2010) (54) Mix 0.67 (0.36 - 1.25) 0.67 (0.40 - 1.12) 0.73 (0.48-1.10) 0.85 (0.60 - 1.19) 0.80 (0.57 - 1.13)b
Jelonek K. (2010) (55) Mix - 0.94 (0.43 - 1.93)b - 0.72 (0.44 - 1.20)b - 0.77 (0.48 - 1.23)b
Ming-Shiean H. (2010) (65) Mix 1.31 (0.83 - 1.96) 1.26 (0.82 - 1.93) 1.05 (0.81–1.38) 1.03 (0.78 - 1.36) 1.12 (0.87 - 1.42) 1.07 (0.82-1.40)b
Romanowicz H. (2010) (74) Post - 2.79 (1.51 - 5.21)b - 1.29 (0.83 - 1.99)b - 1.59 (1.06 - 2.40)b
Santos R. A. (2010) (78) Mix - 0.25 (0.04 - 1.30) - 0.73 (0.30 - 1.40) - 0.60 (0.30 - 1.30)
Sterpone S. (2010) (38) Mix - 4.40 (1.13 - 17.08) - 4.80 (1.56 - 14.78) - 4.66 (1.47 - 15.25)b
Zipprich J. (2010) (89) Mix 0.44 (0.18 - 1.11) - 0.65 (0.39-1.10) - 0.64 (0.41 - 1.00) -
Liu L. (2001) (59) Mix 0.91 (0.66 - 1.27) - 0.87 (0.72–1.05) - 0.88 (0.74 - 1.05) -
Roberts M. R. (2011) (72) Mix
Pre 0.79 (0.44 - 1.42) 0.88 (0.62 – 1.24) 0.86 (0.62 - 1.20)
Post 1.31 (0.94 - 1.83) 1.22 (0.99 – 1.51) 1.24 (1.01 - 1.51)
Hussien Y. M. (2012) (53) Mix 1.60 (0.60 - 4.10) - 1.70 (0.90 – 3.10) - 1.70 (0.90 - 2.90) -
Al Mutairi F. M. (2013) (39) Mix - 1.25 (0.46 - 3.39) - 0.94 (0.51 - 1.72) - 1.00 (0.57 - 1.75)
Przybylowska-Sygut K. (2013) (70) Mix - 0.86 (0.46 - 1.60) - 1.16 (0.76-1.78) - 1.08 (0.70 - 1.65)b
Sapkota Y. (2013) (79) Mix 1.11 (0.94 - 1.31) - 1.12 (1.00 - 1.25) - - -
Ding P. (2014) (46) Mix - 2.69 (1.71 - 4.31)b - 0.89 (0.70 - 1.14)b 1.10 (0.88 - 1.37) 1.09 (0.87 - 1.38)b
Luo H. (2014) (61) Mix 2.18 (1.06 - 4.50) 1.52 (1.01 - 2.31) 1.67 (1.12 - 2.47)
Pre 0.77 (0.20 - 2.91) 1.53 (0.66-3.51) 1.33 (0.60 - 2.91)
Post 2.57 (0.96 - 6.89) 1.84 (1.08-3.15) 1.94 (1.16 - 3.24)
McCullough L. E. (2014) (63) Post - - - - - 1.11 (0.87 - 1.42)b
Ramadan R. A. (2014) (71) Mix 4.42 (1.28 - 15.31) 3.56 (1.22 - 10.39) 2.64 (1.20 – 5.08) 2.62 (1.35 - 5.08) 2.89 (1.35 - 6.21) 2.77 (1.47 - 5.24)
Shadrina A. S. (2014) (80) Mix 1.76 (1.21 - 2.57) - 1.17 (0.92 – 1.51) - 1.29 (1.02 - 1.63) -
Macias-Gomez (2015)N. M. (62) Mix - 2.71 (1.44 - 5.10) - 1.10 (0.80 - 1.51) - 1.27 (0.94 - 1.72)

Abbreviations: CI, confidence interval; OR, odds ratio; USA, United States of America.

aReferences category for calculation of odds ratio.

bORs calculated by authors via Stata software (version 13).