Table 3. Adjusted and Unadjusted Odds Ratio of Studies Assessing the Association Between XRCC1 Arg399Gln Polymorphism and Breast Cancer.
| References | Menopausal Status | Gln/Gln Versus Arg/Arga | Arg/Gln Versus Arg/Arga | Gln/Gln and Arg/Gln Versus Arg/Arga | |||
|---|---|---|---|---|---|---|---|
| Adjusted OR (95% CI) | Unadjusted OR (95% CI) | Adjusted OR (95% CI) | Unadjusted OR (95% CI) | Adjusted OR (95% CI) | Unadjusted OR (95% CI) | ||
| Duell E. J. (African-Americans) (2001) (47) | Mix | - | 2.11 (0.52 - 9.99)b | - | 1.54 (1.03 - 2.32)b | 1.70 (1.10 - 2.40) | - |
| Duell E. J. (Whites) (2001) (47) | Mix | - | 0.84 (0.52 - 1.33)b | - | 1.12 (0.81 - 1.54)b | 1.00 (0.80 - 1.40) | - |
| Kim S. U. (2002) (57) | Mix | 2.40 (1.20 - 4.72) | 0.80 (0.51–1.16) | 0.96 (0.63 - 1.44)b | |||
| Pre | 3.80 (1.44 - 10.30) | 1.20 (0.72–2.10) | 1.51 (0.87 - 2.60)b | ||||
| Post | 1.40 (0.50 - 3.91) | 0.40 (0.19–0.74) | 0.50 (0.25 - 0.98)b | ||||
| Han J. (2003) (51) | Mix | 1.03 (0.77 - 1.37) | 1.06 (0.81 - 1.39) | 1.07 (0.88–1.30) | 1.06 (0.88 - 1.27) | - | 1.04 (0.88 - 1.24)b |
| Moullan N. (2003) (67) | Mix | 1.00 (0.57 - 1.76) | - | 0.96 (0.66–1.40) | - | - | 0.91 (0.64 - 1.29)b |
| Shu X. O. (2003) (82) | Mix | 1.20 (0.85 - 1.69) | 1.22 (0.87 - 1.71) | 0.90 (0.76–1.08) | 0.92 (0.77 - 1.09) | 1.00 (0.84 - 1.18)b | |
| Pre | 1.19 (0.78 - 1.80) | 1.20 (0.79 - 1.81) | 0.79 (0.63–0.98) | 0.79 (0.63 - 0.98) | 0.90 (0.73 - 1.10)b | ||
| post | 1.13 (0.61 - 2.11) | 1.19 (0.65 - 2.17) | 1.19 (0.87–1.62) | 1.21 (0.90 - 1.64) | 1.20 (0.90 - 1.62)b | ||
| Smith T. R. (2003) (84) | Mix | 1.07 (0.58 - 1.96) | - | 1.02 (0.70–1.51) | - | 1.03 (0.71 - 1.49) | - |
| Smith T. R. (2003) (22) | Mix | - | 1.09 (0.54 - 2.16)b | - | 0.81 (0.53 - 1.25)b | - | 0.86 (0.57 - 1.29)b |
| Deligezer U. (2004) (45) | Mix | - | 1.26 (0.61 - 2.61) | - | 0.88 (0.53 - 1.47) | - | 0.96 (0.59 - 1.56) |
| Figueiredo J. C. (2004) (49) | Mix | 0.88 (0.57 - 1.37) | 0.92 (0.60 - 1.41) | 0.91 (0.67-1.23) | 0.92 (0.68 - 1.24) | - | 0.92 (0.68 - 1.23)b |
| Forsti A. (2004) (50) | Mix | - | 0.89 (0.46 - 1.72) | - | 1.10 (0.75 - 1.61) | - | 1.06 (0.73 - 1.52)b |
| Huang C. S. (2004) (52) | Mix | 1.92 (0.79 - 4.69)b | 0.99 (0.61 - 1.60)b | 1.11 (0.71 - 1.75)b | |||
| Chacko P. (2005) (28) | Mix | 2.69 (1.10 - 6.57) | 2.66 (1.10 - 6.40) | 2.04 (1.16-3.58) | 2.02 (1.16 - 3.49) | 2.18 (1.30 - 3.66) | 2.14 (1.29 - 3.58) |
| Pre | 6.32 (2.90 - 13.73) | ||||||
| Post | 0.46 (0.36 - 1.57) | ||||||
| Dufloth R. M. (2005) (48) | Mix | - | 0.89 (0.26 - 2.85)b | - | 0.84 (0.45 - 1.58)b | - | 0.85 (0.47 - 1.54)b |
| Metsola K. (2005) (64) | Mix | 1.39 (0.84 - 2.29) | - | 1.24 (0.93–1.65) | - | 1.26 (0.96 - 1.66) | - |
| Patel A. V. (2005) (69) | Post | 1.27 (0.79 - 2.02) | 1.08 (0.71 - 1.63) | 1.01 (0.73–1.39) | 0.95 (0.71 - 1.27) | 1.06 (0.78 - 1.44) | 0.98 (0.75 - 1.28) |
| Shen J. (2005) (81) | Mix | 0.97 (0.73 - 1.29) | 1.08 (0.90-1.29) | 1.06 (0.89 - 1.26) | |||
| Pre | 1.03 (0.62 - 1.70) | 1.28 (0.93-1.75) | 1.23 (0.91 - 1.66) | ||||
| Post | 1.01 (0.71 - 1.44) | 0.99 (0.79-1.24) | 0.99 (0.80 - 1.24) | ||||
| Brewster A. M. (2006) (41) | Mix | 1.22 (0.73 - 2.06) | 1.11 (0.67 - 1.83) | 1.64 (1.00–2.69) | 1.48 (0.92 - 2.38) | - | 1.24 (0.88 - 1.75)b |
| Bu D. (2006) (42) | Mix | - | 1.10 (0.48 - 2.53) | - | 0.98 (0.58 - 1.65) | - | 1.00 (0.58 - 1.69)b |
| Pachkowski B. F. (African-Americans) (2006) (68) | Mix | 1.80 (0.80 - 3.80) | - | 1.10 (0.90-1.50) | - | 1.20 (0.80 - 1.50) | - |
| Pachkowski B. F. (Whites) (2006) (68) | Mix | 1.00 (0.80 - 1.30) | - | 1.10 (0.90-1.30) | - | 1.10 (0.90 - 1.30) | - |
| Thyagarajan B. (2006) (23) | Mix | 0.91 (0.48 - 1.72) | 0.91 (0.49 - 1.70) | 1.29 (0.84–1.97) | 1.29 (0.85 - 1.95) | 1.20 (0.80 - 1.79) | 1.19 (0.80 - 1.77) |
| Zhai X. (2006) (88) | Mix | 1.01 (0.60 - 1.70) | 0.79 (0.57-1.08) | 0.82 (0.61 - 1.11) | |||
| Pre | 0.83 (0.55 - 1.28) | ||||||
| Post | 0.82 (0.54 - 1.25) | ||||||
| Zhang Y. (USA) (2006) (27) | Mix | 0.90 (0.80 - 1.10) | 1.10 (0.90-1.20) | 1.03 (0.92 - 1.15)b | |||
| Pre | 0.80 (0.60 - 1.10) | 1.00 (0.80-1.20) | 0.92 (0.77 - 1.11)b | ||||
| Post | 1.10 (0.80 - 1.30) | 1.10 (0.90-1.30) | 1.09 (0.95 - 1.26)b | ||||
| Zhang Y. (Poland) (2006) (27) | Mix | 1.10 (0.90 - 1.40) | 1.10 (1.00-1.30) | 1.10 (0.97 - 1.25)b | |||
| Pre | 1.00 (0.70 - 1.50) | 1.20 (0.90-1.50) | 1.12 (0.88 - 1.44)b | ||||
| Post | 1.10 (0.80 - 1.30) | 1.10 (0.90-1.30) | 1.08 (0.92 - 1.25)b | ||||
| Costa S. (2007) (44) | Mix | 0.95 (0.57 - 1.53)b | 0.65 (0.47 - 0.90)b | 1.64 (1.22 - 2.21)b | |||
| Silva S. N. (2007) (21) | Mix | 0.87 (0.50 - 1.49) | 0.80 (0.47 - 1.36) | 0.87 (0.62–1.22) | 0.83 (0.60 - 1.16) | 0.87 (0.63 - 1.20) | 0.83 (0.60 - 1.13) |
| Pre | 0.52 (0.14 - 2.61) | 0.65 (0.14 - 3.04) | 0.49 (0.17–1.42) | 0.49 (0.17 - 1.35) | 0.50 (0.18 - 1.32) | 0.52 (0.20 - 1.32) | |
| Post | |||||||
| Ali M. F. (2008) (40) | Mix | - | 3.54 (0.69 - 10.65)b | - | 1.52 (0.51 - 4.59)b | - | 2.05 (0.76 - 5.61)b |
| Kipikasova L. (2008) (58) | Mix | - | 0.95 (0.39 - 2.27)b | - | 1.25 (0.68 - 2.29)b | - | 1.17 (0.67 - 2.04)b |
| Loizidou M. A. (2008) (60) | Mix | - | 0.90 (0.68 - 1.18) | - | 0.95 (0.80 - 1.14 ) | - | 0.94 (0.79 - 1.11)b |
| Mitra A. K. (2008) (66) | Mix | - | 2.91 (1.66 - 5.10) | - | 0.91 (0.56 - 1.50) | - | 1.41 (0.90 - 2.19) |
| Saadat M. (2008) (77) | Mix | 1.80 (0.90 - 3.61) | 2.01 (1.02 - 3.94) | 0.76 (0.47–1.20) | 0.76 (0.49 - 1.18) | 0.93 (0.61 - 1.44) | 0.95 (0.63 - 1.42) |
| Pre | 1.93 (0.81 - 4.62) | 1.87 (0.81 - 4.37) | 0.88 (0.46–1.67) | 0.84 (0.45 - 1.56) | 1.09 (0.61 - 1.96) | 1.06 (0.60 - 1.85) | |
| Post | 1.20 (0.23 - 6.07) | 1.03 (0.21 - 5.05) | 0.48 (0.18–1.31) | 0.46 (0.17 - 1.21) | 0.57 (0.22 - 1.48) | 0.53 (0.21 - 1.34) | |
| Sangrajrang S. (2008) (29) | Mix | 1.80 (0.99 - 3.29) | 1.74 (0.99 - 3.10) | 1.20 (0.90–1.60) | 1.17 (0.89 - 1.53) | 1.23 (0.94 - 1.61)b1.09 | |
| Pre | 1.45 (0.60 - 3.52) | 1.05 (0.71–1.55) | (0.75 - 1.57)b | ||||
| Post | 1.84 (0.79 - 4.28) | 1.30 (0.84–2.00) | 1.40 (0.93 - 2.11)b | ||||
| Smith T. R. (Caucasian) (2008) (83) | Mix | 0.93 (0.56 - 1.54) | - | 1.01 (0.74-1.40) | - | 1.00 (0.73 - 1.35) | 1.03 (0.75 - 1.40)b |
| Smith T. R. (African-American) (2008) (83) | Mix | 2.19 (0.09 - 52.25) | - | 1.13 (0.44-2.91) | - | 1.18 (0.47 - 2.96) | 1.33 (0.53 - 3.29)b |
| Sobczuk A. (2009) (37) | Post | - | 0.89 (0.42 - 1.84)b | - | 1.09 (0.54 - 2.18)b | - | 0.99 (0.52 - 1.88)b |
| Syamala V. S. (2009) (86) | Mix | - | 1.58 (0.99-2.52)b | - | 1.60 (1.15 - 2.23)b | - | 1.59 (1.17 - 2.16)b |
| Jakubowska A. (2010) (54) | Mix | 0.67 (0.36 - 1.25) | 0.67 (0.40 - 1.12) | 0.73 (0.48-1.10) | 0.85 (0.60 - 1.19) | 0.80 (0.57 - 1.13)b | |
| Jelonek K. (2010) (55) | Mix | - | 0.94 (0.43 - 1.93)b | - | 0.72 (0.44 - 1.20)b | - | 0.77 (0.48 - 1.23)b |
| Ming-Shiean H. (2010) (65) | Mix | 1.31 (0.83 - 1.96) | 1.26 (0.82 - 1.93) | 1.05 (0.81–1.38) | 1.03 (0.78 - 1.36) | 1.12 (0.87 - 1.42) | 1.07 (0.82-1.40)b |
| Romanowicz H. (2010) (74) | Post | - | 2.79 (1.51 - 5.21)b | - | 1.29 (0.83 - 1.99)b | - | 1.59 (1.06 - 2.40)b |
| Santos R. A. (2010) (78) | Mix | - | 0.25 (0.04 - 1.30) | - | 0.73 (0.30 - 1.40) | - | 0.60 (0.30 - 1.30) |
| Sterpone S. (2010) (38) | Mix | - | 4.40 (1.13 - 17.08) | - | 4.80 (1.56 - 14.78) | - | 4.66 (1.47 - 15.25)b |
| Zipprich J. (2010) (89) | Mix | 0.44 (0.18 - 1.11) | - | 0.65 (0.39-1.10) | - | 0.64 (0.41 - 1.00) | - |
| Liu L. (2001) (59) | Mix | 0.91 (0.66 - 1.27) | - | 0.87 (0.72–1.05) | - | 0.88 (0.74 - 1.05) | - |
| Roberts M. R. (2011) (72) | Mix | ||||||
| Pre | 0.79 (0.44 - 1.42) | 0.88 (0.62 – 1.24) | 0.86 (0.62 - 1.20) | ||||
| Post | 1.31 (0.94 - 1.83) | 1.22 (0.99 – 1.51) | 1.24 (1.01 - 1.51) | ||||
| Hussien Y. M. (2012) (53) | Mix | 1.60 (0.60 - 4.10) | - | 1.70 (0.90 – 3.10) | - | 1.70 (0.90 - 2.90) | - |
| Al Mutairi F. M. (2013) (39) | Mix | - | 1.25 (0.46 - 3.39) | - | 0.94 (0.51 - 1.72) | - | 1.00 (0.57 - 1.75) |
| Przybylowska-Sygut K. (2013) (70) | Mix | - | 0.86 (0.46 - 1.60) | - | 1.16 (0.76-1.78) | - | 1.08 (0.70 - 1.65)b |
| Sapkota Y. (2013) (79) | Mix | 1.11 (0.94 - 1.31) | - | 1.12 (1.00 - 1.25) | - | - | - |
| Ding P. (2014) (46) | Mix | - | 2.69 (1.71 - 4.31)b | - | 0.89 (0.70 - 1.14)b | 1.10 (0.88 - 1.37) | 1.09 (0.87 - 1.38)b |
| Luo H. (2014) (61) | Mix | 2.18 (1.06 - 4.50) | 1.52 (1.01 - 2.31) | 1.67 (1.12 - 2.47) | |||
| Pre | 0.77 (0.20 - 2.91) | 1.53 (0.66-3.51) | 1.33 (0.60 - 2.91) | ||||
| Post | 2.57 (0.96 - 6.89) | 1.84 (1.08-3.15) | 1.94 (1.16 - 3.24) | ||||
| McCullough L. E. (2014) (63) | Post | - | - | - | - | - | 1.11 (0.87 - 1.42)b |
| Ramadan R. A. (2014) (71) | Mix | 4.42 (1.28 - 15.31) | 3.56 (1.22 - 10.39) | 2.64 (1.20 – 5.08) | 2.62 (1.35 - 5.08) | 2.89 (1.35 - 6.21) | 2.77 (1.47 - 5.24) |
| Shadrina A. S. (2014) (80) | Mix | 1.76 (1.21 - 2.57) | - | 1.17 (0.92 – 1.51) | - | 1.29 (1.02 - 1.63) | - |
| Macias-Gomez (2015)N. M. (62) | Mix | - | 2.71 (1.44 - 5.10) | - | 1.10 (0.80 - 1.51) | - | 1.27 (0.94 - 1.72) |
Abbreviations: CI, confidence interval; OR, odds ratio; USA, United States of America.
aReferences category for calculation of odds ratio.
bORs calculated by authors via Stata software (version 13).