Table 4. Adjusted and Unadjusted Odds Ratio of Studies Assessing the Association Between OGG1 Ser326Cys Polymorphism and Breast Cancer.
First Author | Menopausal Status | Cys/Cys Versus Ser/Sera | Ser /Cys Versus Ser/Sera | Cys/Cys and Ser /Cys Versus Ser/Sera | |||
---|---|---|---|---|---|---|---|
Adjusted OR (95% CI) | Unadjusted OR (95% CI) | Adjusted OR (95% CI) | Unadjusted OR (95% CI) | Adjusted OR (95% CI) | Unadjusted OR (95% CI) | ||
Choi J. Y. (Korean) (2003) (43) | |||||||
Mix | 1.20 (0.71 - 2.00) | - | 0.90 (0.59 - 1.53) | - | - | 0.94 (0.59 - 1.49)b | |
Pre | 1.10 (0.57 - 2.22) | - | 1.00 (0.56 - 1.93) | - | - | 1.03 (0.55 - 1.91)b | |
Post | 1.10 (0.46 - 2.45) | - | 0.70 (0.34 - 1.63) | - | - | 0.77 (0.37 - 1.64)b | |
Choi J. Y. (Japanese) (2003) (43) | |||||||
Mix | 1.70 (0.93 - 2.96) | - | 1.20 (0.76 - 1.95) | - | - | 1.28 (0.81 - 2.02)b | |
Pre | 1.90 (0.75 - 4.90) | - | 1.30 (0.63 - 2.69) | - | - | 1.32 (0.65 - 2.66)b | |
Post | 1.30 (0.61 - 2.98) | - | 1.20 (0.64 - 2.42) | - | - | 1.23 (0.65 - 2.34)b | |
Vogel U. (2003) (26) | Post | - | 0.98 (0.52 - 1.86) | - | 0.84 (0.64 - 1.10) | - | 0.85 (0.64 - 1.13)b |
Huang C. S. (2004) (52) | Mix | - | 0.82 (0.42 - 1.61)b | - | 0.90 (0.48 - 1.71)b | - | 0.86 (0.48 - 1.58)b |
Cai Q. (2006) (25) | |||||||
Mix | 1.06 (0.83 - 1.35) | - | 1.17 (0.93 - 1.47) | - | - | 1.10 (0.88 - 1.38)b | |
Pre | 0.99 (0.74 - 1.34) | - | 1.08 (0.81 - 1.43) | - | - | 1.04 (0.79 - 1.37)b | |
Post | 1.18 (0.77 - 1.81) | - | 1.37 (0.91 - 2.07) | - | - | 1.26 (0.84 - 1.88)b | |
Rossner P., Jr. (2006) (76) | Mix | 1.01 (0.68 - 1.52) | 0.99 (0.66 - 1.47) | 1.06 (0.88 - 1.28) | 1.04 (0.87 - 1.24) | - | 1.02 (0.86 - 1.22)b |
Zhang Y. (2006) (27) | |||||||
Mix | 1.00 (0.70 - 1.40) | - | 1.00 (0.80 - 1.20) | - | - | 0.98 (0.83 - 1.14)b | |
Pre | 0.90 (0.50 - 1.50) | - | 1.10 (0.80 - 1.40) | - | - | 1.02 (0.78 - 1.32)b | |
Post | 1.20 (0.70 - 1.90) | - | 1.00 (0.80 - 1.20) | - | - | 1.01 (0.82 - 1.25)b | |
Romanowicz-Makowska H. (2008) (75) | Post | - | 0.62 (0.28 - 1.38)b | - | 0.40 (0.18 - 0.87)b | - | 0.49 (0.24 - 0.98)b |
Sangrajrang S. (2008) (29) | |||||||
Mix | 1.42 (0.97 - 2.09) | 1.46 (1.02 - 2.10) | 0.95 (0.67 - 1.34) | 0.99 (0.72 - 1.37) | - | 1.14 (0.83 - 1.56)b | |
Pre | 1.13 (0.67 - 1.91) | - | 0.92 (0.58 - 1.48) | - | - | 1.12 (0.72 - 1.73)b | |
Post | 2.05 (1.14 - 3.69) | - | 0.97 (0.58 - 1.61) | - | - | 1.17 (0.72 - 1.89)b | |
Synowiec E. (2008) (87) | Mix | - | 0.22 (0.04 - 1.04)b | - | 0.33 (0.06 - 1.40)b | - | 0.28 (0.05 - 1.10)b |
Ming-Shiean (2010)H. (65) | Mix | 1.09 (0.74 - 1.59) | 1.09 (0.74 - 1.63) | 0.97 (0.66 - 1.42) | 0.99 (0.67 - 1.47) | 1.04 (0.80 - 1.46) | 1.02 (0.71 - 1.48)b |
Sterpone S. (2010) (38) | Mix | - | 0.83 (0.10 - 6.65) | - | 1.37 (0.53 - 3.56) | - | 1.03 (0.46 - 3.64)b |
Roberts M. (2011)R. (72) | |||||||
Mix | - | - | - | - | - | - | |
Pre | 1.17 (0.53 - 2.54) | - | 1.00 (0.72 - 1.38) | - | 1.01 (0.74 - 1.38) | - | |
Post | 1.19 (0.77 - 1.85) | - | 0.97 (0.79 - 1.19) | - | 0.99 (0.82 - 1.21) | - | |
Kim K. Y. (2013) (57) | Mix | - | 0.83 (0.53 - 1.30)b | - | 0.95 (0.66 - 1.38)b | 0.90 (0.64 - 1.27) | 0.91 (0.64 - 1.30)b |
Xie H. (2013) (12) | |||||||
Mix | - | 1.34 (0.97 - 1.84) | - | 1.10 (0.82 - 1.49) | - | 1.19 (0.88 - 1.60)b | |
Pre | - | 1.87 (1.14 - 3.06) | - | 1.08 (0.68 - 1.72) | - | 1.34 (0.84 - 2.15)b | |
Post | - | 1.18 (0.73 - 1.89) | - | 1.02 (0.66 - 1.57) | - | 1.07 (0.69 - 1.65)b | |
Luo H. (2014) (61) | |||||||
Mix | 0.69 (0.40 - 1.19) | - | 0.82 (0.48 - 1.38) | - | 0.76 (0.46 - 1.24) | - | |
Pre | 0.41 (0.14 - 1.18) | - | 0.58 (0.21 - 1.64) | - | 0.49 (0.19 - 1.27) | - | |
Post | 0.83 (0.40 - 1.70) | - | 1.01 (0.51 - 1.99) | - | 0.93 (0.49 - 1.76) | - | |
McCullough L. E. (2014) (63) | Post | - | - | - | - | - | 0.98 (0.77 - 1.25)b |
Rodrigues P. (2014) (73) | Mix | - | - | - | - | 1.82 (1.31 - 2.52)c | - |
Smolarz B. (2014) (85) | Mix | - | 0.93 (0.34 - 2.51) | - | 1.02 (0.45 - 2.34) | - | 1.00 (0.42 - 2.37)b |
Abbreviations: CI, confidence interval; OR, odds ratio.
aReferences category for calculation of odds ratio.
bORs calculated by authors via Stata software (version 13).
cCys/Cys versus Ser /Cys and Ser/Ser; Cys/Cys as reference category.