Appendix A7. Characteristics of Literature Included in the Systematic Review Evaluating the Association Between XRCC1 Arg280His Polymorphism and Breast Cancer a.
| First Author | Date | Country | Ethnicity | Study Design | Control Source | Genotyping Methods | Analyzed Sample Size (Case Number) | Minor Allele Frequency (Case/Control) | Considered Confounders b |
|---|---|---|---|---|---|---|---|---|---|
| Moullan, N. | 2003 | France | NS | hospital based | population based | TaqMan technology or variant specific restriction enzyme digestion | 566 (254) | (0.08/0.04) | age |
| Chacko, P. | 2005 | India | NS | hospital based | hospital based | PCR-RFLP and DNA sequencing techniques | 246 (123) | (0.11/0.14) | age and menopausal status |
| Metsola, K. | 2005 | Finland | Caucasian | hospital based | population based | PCR-RFLP | 959 (480) | (0.08/0.07) | age, age at menarche, age at first full term pregnancy, number of pregnancies, history of benign breast disease, first degree family history of breast cancer, waist-to-hip ratio, smoking and use of alcohol |
| Pachkowski, B. F. | 2006 | USA | African Americans | population based | population based | the ABI 7700 sequence detection system or ‘‘Taqman’’ assay | 1446 (765) | (0.04/0.03) | offsets and age |
| Pachkowski, B. F. | 2006 | USA | Whites | population based | population based | the ABI 7700 sequence detection system or ‘‘Taqman’’ assay | 2400 (1271) | (0.05/0.04) | offsets and age |
| Zhang, Y. | 2006 | USA | Caucasian | population based | population based | TaqMan | 2802 (1564) | (0.05/0.04) | age and study site |
| Loizidou, M. A. | 2008 | Greece | Greek Cypriots | population based | volunteers | PCR-RFLP | 2277 (1109) | ( 0.08/0.09) | - |
| Sangrajrang, S. | 2008 | Thailand | NS | hospital based | hospital based | rapid capillary PCR followed by melting curve analysis using fluorescence labeled hybridization probes in a light cycler | 932 (507) | (0.08/0.07) | age, body mass index, age at menarche, family history of breast cancer, reproduction parameters, use of contraceptives, menopausal status, hazardous lifestyle, and education |
| Smith, T. R. | 2008 | USA | Caucasian | hospital based | hospital based | mass ARRAY system | 732 (324) | (0.04/0.05) | age, family history of breast cancer, smoking history, age at menarche, age at first live birth and body mass index |
| Smith, T. R. | 2008 | USA | African-American | hospital based | hospital based | mass ARRAY system | 128 (53) | (0.03/0.04) | age, family history of breast cancer, smoking history, age at menarche, age at first live birth and body mass index |
| Zipprich, J. | 2010 | USA | NS | population based | population based | fluorescence polarization method | 599 (271) | NC | menopause and age and age at menarche |
| Liu, L. | 2011 | China | Han Chinese | hospital based | population based | PCR-RFLP | 1999 (995) | (0.09/0.10) | age |
a Definitions: Date, year of publication; NS, not state; NC, not calculable; USA, United State of America.
b Confounders in multivariate analysis.