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. 2016 Feb 23;9(1):e3467. doi: 10.17795/ijcp-3467

Appendix A7. Characteristics of Literature Included in the Systematic Review Evaluating the Association Between XRCC1 Arg280His Polymorphism and Breast Cancer a.

First Author Date Country Ethnicity Study Design Control Source Genotyping Methods Analyzed Sample Size (Case Number) Minor Allele Frequency (Case/Control) Considered Confounders b
Moullan, N. 2003 France NS hospital based population based TaqMan technology or variant specific restriction enzyme digestion 566 (254) (0.08/0.04) age
Chacko, P. 2005 India NS hospital based hospital based PCR-RFLP and DNA sequencing techniques 246 (123) (0.11/0.14) age and menopausal status
Metsola, K. 2005 Finland Caucasian hospital based population based PCR-RFLP 959 (480) (0.08/0.07) age, age at menarche, age at first full term pregnancy, number of pregnancies, history of benign breast disease, first degree family history of breast cancer, waist-to-hip ratio, smoking and use of alcohol
Pachkowski, B. F. 2006 USA African Americans population based population based the ABI 7700 sequence detection system or ‘‘Taqman’’ assay 1446 (765) (0.04/0.03) offsets and age
Pachkowski, B. F. 2006 USA Whites population based population based the ABI 7700 sequence detection system or ‘‘Taqman’’ assay 2400 (1271) (0.05/0.04) offsets and age
Zhang, Y. 2006 USA Caucasian population based population based TaqMan 2802 (1564) (0.05/0.04) age and study site
Loizidou, M. A. 2008 Greece Greek Cypriots population based volunteers PCR-RFLP 2277 (1109) ( 0.08/0.09) -
Sangrajrang, S. 2008 Thailand NS hospital based hospital based rapid capillary PCR followed by melting curve analysis using fluorescence labeled hybridization probes in a light cycler 932 (507) (0.08/0.07) age, body mass index, age at menarche, family history of breast cancer, reproduction parameters, use of contraceptives, menopausal status, hazardous lifestyle, and education
Smith, T. R. 2008 USA Caucasian hospital based hospital based mass ARRAY system 732 (324) (0.04/0.05) age, family history of breast cancer, smoking history, age at menarche, age at first live birth and body mass index
Smith, T. R. 2008 USA African-American hospital based hospital based mass ARRAY system 128 (53) (0.03/0.04) age, family history of breast cancer, smoking history, age at menarche, age at first live birth and body mass index
Zipprich, J. 2010 USA NS population based population based fluorescence polarization method 599 (271) NC menopause and age and age at menarche
Liu, L. 2011 China Han Chinese hospital based population based PCR-RFLP 1999 (995) (0.09/0.10) age

a Definitions: Date, year of publication; NS, not state; NC, not calculable; USA, United State of America.

b Confounders in multivariate analysis.