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Chip-based material delivery. a) Schematic illustration of cell deformation in microchannels for material delivery. When cells pass through microchannels, the rapid deformation generates membrane holes enabling the delivery from outside to inside. Reproduced with permission.[77b] Copyright 2013, National Academy of Sciences. b) The same mechanism enables the delivery of CRISPR-Cas9 into cells for gene editing. Reproduced with permission.[77a] Copyright 2015, AAAS.
