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. Author manuscript; available in PMC: 2017 Apr 22.
Published in final edited form as: Mol Biosyst. 2016 Feb 19;12(4):1090–1105. doi: 10.1039/c6mb00014b

Fig. 7.

Fig. 7

Schematic of the effect of hyperglycemia on pathway activation in human retinal pigment epithelium cells. Cells were cultured in either unlabeled D-glucose (5.5 mM) or D-[U–13C]-glucose (25 mM), and metabolite labeling was assessed using the automated untargeted isotope analysis program geoRge. Adapted from J. Capellades, M. Navarro, S. Samino, M. Garcia-Ramirez, C. Hernandez, R. Simo, M. Vinaixa and O. Yanes, Anal. Chem., 2016, 88, 621–628. Used with permission.