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. Author manuscript; available in PMC: 2016 Nov 4.
Published in final edited form as: Nature. 2016 May 4;533(7604):481–486. doi: 10.1038/nature17998

Extended Data Figure 6. (2R,6R)-hydroxynorketamine rapidly increases the frequency and amplitude of AMPA receptor spontaneous excitatory postsynaptic currents in the hippocampus.

Extended Data Figure 6

a, Representative traces of spontaneous excitatory postsynaptic currents (sEPSCs) mediated via AMPA receptors during baseline (before) and 20 min following drug administration (after) in b, example CA1 stratum radiatum interneuron recorded from a rat hippocampal slice. (c-j) Twenty-min exposure of (e,i), (2R,6R)-hydroxynorketamine (HNK), but not (c,g), (R,S)-ketamine (KET) or (d,h), (2S,6S)-HNK increased AMPA sEPSCs frequency and amplitude compared to baseline. Data are means ± S.E.M. *p<0.05, **p<0.01, ***p<0.001 (statistical analyses and n numbers see Supplementary Information Table 1). Abbreviations: FST, forced-swim test; NBQX, 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo[f]quinoxaline-2,3-dione; SAL, saline; SLM, stratum lacunosum-moleculare; SO, stratum oriens; SP, stratum pyramidale; SR, stratum radiatum.