Extended Data Figure 9. (2R,6R)-hydroxynorketamine administration does not alter startle amplitude, self-administration drug intake or drug discrimination response rate.

a, Startle amplitude as measured in the pre-pulse inhibition task was not affected by administration of (R,S)-ketamine (KET) or (2R,6R)-hydroxynorketamine (HNK). (b,c), Response rate of overall lever pressing per sec in the drug discrimination paradigm was not changed by administration of b, (R,S)-KET, (2R,6R)-HNK or c, phencyclidine (PCP). d, Unlike ketamine, (2R,6R)-HNK did not alter drug intake in the self-administration task in mice. Data are means ± S.E.M. *p<0.05 (statistical analyses and n numbers see Supplementary Information Table 1). SAL, saline.