Extended Data Figure 2. Circulating levels of ketamine and its metabolites following i.p. administration in mice.

a, Plasma and b, brain levels of ketamine (KET) and its metabolites following administration of (R,S)-KET (10 mg/kg) in mice. (c-d) Brain levels of c, KET, d, norketamine (norKET) and e, hydroxynorketamine (HNK) following administration of (S)- and (R)-KET. f, Chemical structure of (R,S)-6,6-dideuteroketamine ((R,S)-d₂-KET), which g, displaces [³H]-MK-801 binding with a similar affinity to (R,S)-KET ((R,S)-KET: Ki=799nM (R,S)-d₂-KET: Ki=883nM) (statistical analyses and n numbers see Supplementary Information Table 1).