Extended Data Figure 4. Locomotor effects of (R,S)-ketamine and (R,S)-6,6-dideuteroketamine.

After recording baseline activity for 60 min, mice received drug (marked by a vertical dashed line) and locomotor activity was monitored for another 1 hour. (a,b), Administration of (R,S)-KET (10 mg/kg), induced hyper-locomotor responses equally in both male and female mice. (c,d), (R,S)-ketamine (KET) and (R,S)-6,6-dideuteroketamine ((R,S)-d₂-KET) were equally potent in inducing a hyper-locomotor response at the dose of 10 mg/kg. Data are means ± S.E.M. *p<0.05, **p<0.01. SAL, saline (statistical analyses and n numbers see Supplementary Information Table 1).