Table II.
Clinical and biochemical characteristics of obese adolescents with normal glucose tolerance (NGT) and prediabetes.
| Normal glucose tolerance mean (SD) | Prediabetes mean (SD) | P value | |
|---|---|---|---|
|
| |||
| N (%) | 45 (62.5%) | 27 (37.5%) | |
|
| |||
| Age (years) | 12.8 (2.5) | 14.0 (2.4) | 0.0435* |
|
| |||
| Gender | |||
| Male | 31 (68.9%) | 13 (48.1%) | 0.0805* |
| Female | 14 (31.1%) | 14 (51.9%) | |
|
| |||
| BMI (kg/m2) | 31.9 (4.8) | 33.6 (6.2) | 0.2919 |
|
| |||
| BMI SDS | 3.0 (1.1) | 2.9 (0.8) | 0.5337 |
|
| |||
| Puberty | |||
| Early (T 2–3) | 17 | 10 | 0.0382* |
| Late (T 4–5) | 28 | 17 | |
|
| |||
| Fasting glucose (mmol/L) | 4.4 (0.6) | 5.3 (2.3) | <0.0005* |
|
| |||
| Glucose 30 min (mmol/L) | 7.0 (1.3) | 8.7 (1.3) | <0.0005* |
|
| |||
| Glucose 60 min (mmol/L) | 6.1 (1.6) | 8.8 (1.9) | <0.0005 |
|
| |||
| Glucose 90 min (mmol/L) | 5.8 (1.2) | 8.0 (1.9) | <0.0005* |
|
| |||
| Glucose 120 min (mmol/L) | 5.4 (1.0) | 7.7 (1.8) | <0.0005* |
|
| |||
| Fasting insulin (μU/mL) | 21.5 (19.7) | 22.6 (10.0) | 0.2145 |
|
| |||
| HOMA | 4.3 (4.1) | 5.3 (2.3) | 0.0070* |
|
| |||
| IGI (μU/mg) | 4.0 (2.9) | 2.1 (1.6) | 0.0009* |
|
| |||
| QUICKI | 0.32 (0.04) | 0.31 (0.04) | 0.0194* |
|
| |||
| WBISI | 3.1 (1.9) | 1.9 (0.9) | 0.004* |
|
| |||
| HOMA %B | 208.7 (63.6) | 176.0 (59.2) | 0.0420* |
|
| |||
| HbA1c | 5.4 (0.3) | 5.8 (0.4) | 0.0014* |
| N | 26 (57.7%) | 16 (59%) | |
SDS – Standard deviation score, IGI – insulinogenic index, HOMA%B – HOMA-derived β–cell function, WBISI – Whole Body Insulin Sensitivity Index.