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. Author manuscript; available in PMC: 2016 Jun 27.
Published in final edited form as: Nat Rev Nephrol. 2014 Sep 30;10(11):625–643. doi: 10.1038/nrneph.2014.170

Figure 2. Ontogeny of renal-resident DC and Mac.

Figure 2

Bone marrow-resident monocyte-dendritic cell precursors (MDP) release monocytes to the peripheral circulation under homeostatic and inflammatory conditions. Cells also develop into common and pre-DC precursors (CDP and pre-DC) that migrate from blood to the renal interstitial compartment, with regular turnover. Pre-DC under the influence of different growth factors, become distinct, tissue-based subsets (broadly characterized as CX3CR1+ or CD103+) capable of exodus to the draining lymph node for antigen presentation to T cells. Pre-DC also give rise to plasmacytoid DC (pDC), although their presence in murine kidney is disputed.