Table 2.
Inactivation |
Activation |
Time Course |
||||||
---|---|---|---|---|---|---|---|---|
Current/VGN Subpopulation | V1/2, mV | s, mV | V1/2, mV | s, mV | G density, nS/pF | tpeak, 0 mV, ms | tpeak, −15 mV, ms | τinact, 0 mV, ms |
NaV (total) | ||||||||
VGNs with INaI | −76.9 ± 1.5 (13) | 7.5 ± 0.4 (13) | −40.1 ± 2.0 (6) | 6.0 ± 0.6 (6) | 8.4 ± 0.9 (6) | 0.33 ± 0.03 (8) | 0.42 ± 0.03 (10) | 0.26 ± 0.02 (10) |
VGNs without INaI or INaR | −79.5 ± 1.3 (3) | 6.6 ± 0.2 (3) | −38.6 (1) | 6.2 (1) | 7.24 (1) | 0.25 ± 0.003 (3) | 0.31 ± 0.01 (5) | 0.21 ± 0.01 (4) |
cultured VGNs | −76.3 ± 0.2 (12) | 7.6 ± 0.1 (12) | −36.5 ± 1.6 (11) | 5.7 ± 0.4 (11) | 8.7 ± 1.0 (11) | 0.36 ± 0.01 (8) | 0.45 ± 0.01 (8) | 0.28 ± 0.01 (8) |
NaS | ||||||||
VGNs with INaI | −74.6 ± 1.5 (13) | 7.0 ± 0.3 (13) | −39.8 ± 2.5 (6) | 5.7 ± 0.8 (6) | 6.1 ± 0.4 (6) | 0.32 ± 0.03 (7) | 0.40 ± 0.04 (8) | 0.25 ± 0.02 (7) |
VGNs with INaR | −65.8 ± 1.6 (8) | 10.5 ± 0.3 (8) | −32.3 ± 0.7 (6) | 5.9 ± 0.5 (6) | 3.1 ± 0.34 (5) | 0.45 ± 0.04 (5) | 0.57 ± 0.03 (5) | 0.312 ± 0.01 (5) |
NaI | ||||||||
VGNs with INaI + INaS | −102.1 ± 1.3 (23) | 9.9 ± 0.6 (23) | −47.5 ± 1.6 (9) | 8.2 ± 0.4 (9) | 1.0 ± 0.2 (9) | 0.47 ± 0.03 (9) | 0.53 ± 0.03 (11) | 0.27 ± 0.03 (8) |
NaR | ||||||||
VGNs with INaR + INaS | −31.4 ± 0.6 (23) | 5.2 ± 0.2 (23) | −16.5 ± 0.6 (8) | 4.5 ± 0.2 (8) | 1.5 ± 0.3 (7) | 1.4 ± 0.1 (6) | 3.1 ± 0.2 (6) | 2.4 ± 0.1 (11) |
Values are means ± SE (n). Sample sizes were smaller for activation parameters because higher recording quality is required. Room temperature, Cs+ internal, and Cs+ external solutions (Table 1). VGN, vestibular ganglion neurons; see text for additional definitions.