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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Microbiol Spectr. 2016 Jun;4(3):10.1128/microbiolspec.VMBF-0027-2015. doi: 10.1128/microbiolspec.VMBF-0027-2015

Table 2. Summary of bacterial mechanisms for metal ion acquisition.

Pathogens Infection site (model) Ion System contributing to virulence Ref.
S. Typhimurium Systemic infection (mice) Fe EntC, EntB, IroN (salmochelin/enterobactin) (62)
Streptococcus suis Systemic infection (mice) Fe FeoB, iron transporter (56)
Campylobacter jejuni Gastrointestinal tract (chick) Fe FeoB, iron transporter (58)
Staphylococcus aureus Systemic infection (mice) Fe Isd heme uptake system (69)
Yersinia pestis Systemic infection/bubonic plaque (mice) Fe Yef and Feo iron transporter (127)
Staphylococcus aureus Systemic infection (mice) Mn MntABC and MntH Mn transporters (82)
Escherichia coli (UPEC) Bladder and kidney (mice) Zn ZnuABC and ZupT Zn transporters (86)
S. Typhimurium Inflammed gut (mice) Zn ZnuABC Zn uptake system (84)
Acinetobacter baumannii Lungs (mice) Zn ZnuABC Zn uptake system (83)
Mycobacterium tuberculosis Differentiated human macrophages Zn CtpC P1-type ATPase, Zn efflux system (85)
Mycobacterium tuberculosis Lung and lymph nodes (Guinea pigs) Cu MctB copper transport protein B (95)
Escherichia coli Mouse macrophage-like cells Cu CopA ATPase, Cu+ export system (89)
Escherichia coli (UPEC) Bladder (mice) Cu Yersinibactin (96)
Pseudomonas aeruginosa Systemic infection (mice) Cu CopA1 P-type ATPase, Cu+ efflux system (94)