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. Author manuscript; available in PMC: 2016 Dec 8.
Published in final edited form as: Nature. 2016 Jun 8;534(7606):213–217. doi: 10.1038/nature18309

Fig. 5.

Fig. 5

Chronic increases in whole-body acetate turnover promote hyperphagia, obesity, and metabolic syndrome. (a) Plasma insulin during a hyperglycemic clamp. In all panels, *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001 vs. controls; §P<0.05, §§P<0.01, §§§P<0.001, §§§§P<0.0001 vs. acetate treated. n=6 replicates unless otherwise stated. (b), (c) Plasma gastrin and ghrelin at time 0 of the hyperglycemic clamp. (d) Weight change during the ten-day infusion (n=16 controls, 16 acetate, and 12 acetate + vagotomy). (e), (f) Liver and skeletal muscle triglyceride content. (g) Endogenous glucose production during a hyperinsulinemic-euglycemic clamp. (h) Glucose disposal rate during the clamp. All data are the mean ± S.E.M.