FIG. 2.

Comparison of obvious phenotypes between Nrf2 mutant mice and Nrf2 mutant rats. Nrf2 mutant rats with Δ7 or +1 mutations (14–20 weeks old, 6–11 rats) and Nrf2 knockout mice (11–15 weeks old) were used. A, Color of incisors. Absence (B) or presence (C) of a congenital intrahepatic shunt was determined by cannulation of the portal vein with a catheter, opening of the inferior vena cava and flushing the liver with saline. A solution of bromophenol blue was then perfused into the portal vein. The liver was then excised and photographed. Representative photographs are shown with illustrations. IVC, inferior vena cava. D, Percentages of rats with shunt were calculated. E, Percentages of liver weight to body weight were calculated after injection of bromophenol blue. **P < .01.