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. 2016 Apr 12;152(1):40–52. doi: 10.1093/toxsci/kfw065

FIG. 7.

FIG. 7.

Effects of repeated doses of AFB1 with CDDO-Im in wild-type and Nrf2 knockout rats with Δ7 mutation. A, Schedule of treatment of CDDO-Im and AFB1. Rats were gavaged with CDDO-Im (30 μmol/kg body weight) for 3 successive weeks on Monday, Wednesday, and Friday at 8 am. Beginning on the first week, AFB1 (25 μg/rat) was gavaged at 12 am Monday through Friday for 2 weeks. Rats were sacrificed 5 weeks after the last doses of CDDO-Im and AFB1. B, Change of body weight. Rats (104–168 g on the first day of administration of AFB1) were used. Body weight on the first day of administration of AFB1 was set to 100%. The data represent mean ± SD (n = 5–8). C, Survival rate. Four groups were listed in the table. **P < .01. Asterisks with brackets indicate the comparison between indicated groups.