Table 1. Data sources and corresponding identifiers for the protein similarity matrices employed in this work.

Data Source	Name	Description
Pfam/UniProt	uniprotA	UniProt ID for protein A
	uniprotB	UniProt ID for protein B
Needleman-Wunsch	seqAliG	Global sequence alignment score
Smith-Waterman	seqAliL	Local sequence alignment score
TM-Align	strAliSize	Structural alignment size
	strAliId	Structural alignment identity percentage
	strAliScr	Structural alignment TM-score
CSM	csmDist	Structural signature array distances
STRING	neighborhood	Conserved gene neighborhood score
	fusion	Gene fusion score
	cooccurrence	Co-occurrence score
	coexpression	Co-expression score
EMBOSS Pepstats	difMolWeight	Difference in molecular weights
	difIsoPoint	Difference in isoelectric points
	difAliphRes	Difference in aliphatic residue contents
	difAromRes	Difference in aromatic residue contents
	difPolarRes	Difference in polar residue contents
	difChargedRes	Difference in charged residue contents
	difBasicRes	Difference in basic residue contents
	difAcidicRes	Difference in acid residue contents
	aaCompDist	Amino acid composition array distance
ExPASy ProtParam	difInstab	Difference in instability indices
	difGRAVY	Difference in GRAVY indices
InterPro	interpro	Number of common annotations
Gene Ontology	go	Number of common terms
Putative active site	ASid	Putative active site identity percentage
	ASscr	Putative active site BLOSUM62 score