Fig. 7.

Imaging spatiotemporal dynamics of cortical activity during a visual discrimination task. A: tracks of locomotor response during behavior for trials where the animal responded left vs. right. Correct trials, green; incorrect trials, magenta. B: average neural activity in individual subjects averaged across multiple imaging sessions for trials when the animal responded between 400 and 600 ms after stimulus onset, showing distinct patterns of activation across cortical areas at 100 ms intervals. Each row represents an individual subject. Inset shows positioning of cranial window. C: average neural activity aligned across 15 sessions in 5 subjects, with overlay of putative area boundaries from corresponding retinotopic mapping, showing temporally specific activation of restricted cortical areas that is consistent across subjects. Scale bars, 1 mm. Arrow shows small region between lateral extrastriate, barrel, and auditory cortex active throughout the trial. D: average time course at 3 cortical locations marked by colored squares in C, corresponding to V1 (blue), RL (green), and S1 (red). Response is normalized to maximum for each location to demonstrate differences in temporal activation. Gray box shows response window. E: average time course as in D, without temporal deconvolution.