Fig. 1.

Biophysical model implementation: model representation with recurrent network (red arrows, for clarity only the main connections are represented) connecting 6 populations of neurons (excitatory: pyramidal and spiny stellate cells; and inhibitory: smooth stellate cells) in the 3 main layers of the cortical structure, background activity (green arrows) simulating realistic synaptic bombardment to embed the column into a larger network, lateral connections between neighboring columns (blue dashed arrows), and input signals from the thalamus (large red arrow). The model offers the possibility to compute the voltage-sensitive dye (VSD) signal with a linear formula taking into account the dye concentration (blue gradient), and the membrane potential at each compartment. [Reprinted from Neuroimage, Vol. 53, Chemla and Chavane, “A biophysical cortical column model to study the multi-component origin of the VSDI signal,” Pages 420–438, Copyright (2010), with permission from Elsevier.]