Fig. 6.

RH1691 specific effects on the modeled VSD signal. A, top: VSD responses before (gray-scale traces) and after (red traces) a 32% modulation of τ_G (2, 5, and 20 ms are plotted in columns) for 2 thalamic input rates (10 and 40 ips). Corresponding normalized differences [df = (f_mod − f)/f] are plotted at bottom, where shaded gray areas represent means ± SE. B: similarly to the VSD dynamics, normalized differences of the input response function of the VSD signal are computed and plotted here for the three different values of τ_G (2, 5, and 20 ms, gray-scale and markers). C: statistical effect of a 32% prolongation of τ_G on the principal VSD time course characteristics. The normalized differences in plateau amplitude (blue), time constants (τ_on and τ_off, pink and yellow), and notch amplitude (green) are respectively shown in top, middle, and bottom. D: statistical effect of a 32% prolongation of τ_G on the input response function parameters. The normalized differences in R_max (blue) and I₅₀ (red) are, respectively, shown at top and bottom. Error bars are means ± SE. *Significant differences (see materials and methods, P < 0.01).