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. 2015 Nov 5;1(1):dvv006. doi: 10.1093/eep/dvv006

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© The Author 2015. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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genomic distribution of RAMs. TSRs are defined genomic regions where experimentally verified transcriptional initiation has taken place. Exons are regions of coding sequence. Promoters are defined as −500 to +100 of the TSR. Gene locus encompasses the entirety of the gene, including introns. Intergenic regions are defined as regions outside genic and regulatory regions. Repeats are matched against the UCSC Genome Browser RepeatMasker track. (A) A greater percentage of RAMs overlap with exons than TSRs or promoters and have >2-fold higher RAMs overlapping in the relatively higher exposure group, for all comparisons. (B) Among gene locus, intergenic regions, introns, and repeats, only hypermethylated RAMs overlapping with repetitive regions are less in the relatively higher exposure groups