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. Author manuscript; available in PMC: 2016 Jun 27.
Published in final edited form as: Transl Res. 2015 Sep 18;166(6):554–567. doi: 10.1016/j.trsl.2015.09.004

Figure 4. Bleomycin (BLM)-induced increase in markers of pulmonary fibrosis in the lungs of old male C57BL/6 are only inhibited by young adipose derived mesenchymal stem cells (yASC) not old ASCs (oASC).

Figure 4

A) Ashcroft scores were used to evaluate the degree of fibrosis. Data are graphed as the mean score of 32 fields/section of lung. Saline (n=8), BLM (n=8), BLM+yASCs (n=5), BLM+oASCs (n=7). B) Collagen content was estimated by hydroxyproline assay as described in methods. Data are graphed as μg/mg of lung tissue. Saline (n=8), BLM (n=8), BLM+yASCs (n=7), BLM+oASCs (n=8). C) αv-integrin mRNA expression was determined by RT-PCR as a marker of fibrosis. Data are graphed normalized for 18S content. Saline (n=7), BLM (n=12), BLM+yASCs (n=5), BLM+oASCs (n=5), *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.