Figure 4. Patient 2 achieved a durable CR after 2 infusions of κ.CARTs.
Patient 2 had transformed follicular lymphoma (FL) with active disease in the neck 4 weeks after receiving 1 dose of bendamustine, as documented in the preinfusion PET/CT scan, which showed a hypermetabolic 7.2 × 3.4-cm left anterior mass (circled) and a hypermetabolic 1.7 × 1-cm left paratracheal lymph node. Six weeks after the first infusion of κ.CARTs, a PET/CT scan showed a PR, with a decrease in the activity and size of the mass (2.4 × 0.8 cm) and lymph node (1.3 × 0.6 cm). Another PET scan obtained after a second infusion was consistent with a CR. This patient has been without evidence of disease for almost 3 years.