Figure 5. Patient 9 achieved a transient CR after 3 infusions of κ.CARTs.

Patient 9 had transformed FL with active disease in the retroperitoneum and pelvis, including a 2.1 × 1.2-cm left external iliac lymph node near the anterior aspect of the left acetabulum, with a standard uptake value (SUV) of 8.5 (bottom row) and a 1 × 1-cm posterior left common iliac chain lymph node, with an SUV of 4.4 (top row). Six weeks after the first infusion of κ.CARTs, a repeat PET/CT scan showed interval improvement in uptake and, to a lesser degree, in the size of multiple lymph nodes, including mild interval improvement in uptake (SUV 5.5) and size (2 × 0.9-cm) in the external iliac lymph node and improved uptake (SUV 3.4) and a slight decrease in the size of the common iliac lymph node. Six weeks after the second infusion of κ.CARTs, we observed a significant response with what appeared to be residual disease within the left pelvic lymph nodes, with the external iliac lymph node that had remained stable in size but had decreased to an SUV of 2.9 and the common iliac lymph node with an SUV of 2.2. Six weeks after the third infusion of κ.CARTs, there was a decrease in the size (the external iliac lymph node was 1.7 × 0.9 cm) and resolution of the previous uptake within the left pelvic lymph nodes and normal uptake elsewhere, consistent with a CR.