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. 2016 Jun 6;126(7):2597–2609. doi: 10.1172/JCI86198

Figure 4. Longitudinal lesion volume and T1-hypointensity assessment.

Figure 4

(A) Semilogarithmic plot of the longitudinal volume for each lesion according to participant age and lesion group (G1, G2, G3). Three main observations about centripetal lesions with persistent phase rim derive from this graph: (a) their lesion volume shrinkage over time tends to plateau after the first 3 months; (b) their mean lesion volume is higher at all time points; and (c) compared with centripetal lesions with transient phase rims, they tend to occur in older individuals. (B) Percentage of lesion volume shrinkage (mean ± SD) between M3 and M12 for each lesion group. (C) Lesional T1 hypointensity at M12 for each lesion group (mean ± SD; T1 signal intensity is expressed in units of SD of normal-appearing white matter signal). In G1, red dots show the in vivo mean T1 hypointensity of the 5 pathologically assessed demyelinated lesions with phase rim. G1: centripetal lesions with persistent phase rim; G2: centripetal lesions with transient phase rim; G3: centrifugal lesions.