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. 2016 May 23;126(7):2465–2481. doi: 10.1172/JCI82925

Figure 8. Effects of bone marrow ablation and reconstitution between Arg2 KO and WT in the OVA/OVA asthma model.

Figure 8

(A) Arg2 KO and WT underwent bone marrow ablation and reconstitution, then OVA sensitization and challenge. (B–F) Total cells (B), eosinophils (C), eotaxin-1 (D), IL-13 (E), and IL-17 (F) in BAL of Arg2 KO and WT receiving bone marrow transplant from Arg2 KO or WT in the OVA/OVA asthma model. n ≥ 4 replicate experiments. #P = 0.01, Arg2 KO recipients receiving bone marrow from Arg2 KO vs. WT, 2-tailed t test. (G) Quantification of PAS staining in airways of Arg2 KO and WT mice receiving bone marrow from Arg2 KO or WT in the OVA/OVA model. n ≥ 4 replicate experiments. Two-tailed t test. (H−O) Airway goblet cell metaplasia (PAS staining) in airways of Arg2 KO and WT receiving bone marrow from Arg2 KO or WT in the OVA/OVA model. I, close-up view of H, K of J, M of L, and O of N. n ≥ 4 replicate experiments. Black arrows show inflammatory infiltrate; arrowheads, PAS+ staining. a, airways. Scale bars: 40 μm.