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. 2016 Jun 6;126(7):2547–2560. doi: 10.1172/JCI83817

Figure 2. A molecular site for the actions of 2,6-DTBP on α3GlyRs.

Figure 2

(A) Concentration-response curves of glycine in wild-type and (F388A) point-mutated α3GlyRs. (B) Traces of glycine-activated whole-cell currents recorded from cells expressing wild-type or (F388A) point-mutated α3GlyRs in the absence or presence of 2,6-DTBP (100 μM). (C) Concentration-response curves of 2,6-DTBP for wild-type and (F388A) point-mutated α3GlyRs. (D) Examples of single-channel recordings from membranes expressing point-mutated (F388A) α3GlyRs in the presence or absence of 2,6-DTBP. (E) Ion channel nPo of the (F388A) α3GlyR in the absence or presence of 2,6-DTBP (10 μM). (F) Percentage change of nPo following the application of 2,6-DTBP in wild-type and (F388A) point-mutated α3GlyRs. ***P < 0.001, unpaired t test. All data are the mean ± SEM from 6 to 9 cells per group.