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. 2016 Jun 13;126(7):2626–2641. doi: 10.1172/JCI84637

Figure 2. Notch signaling is dispensable for initiation and progression of prostate cancer in the Pten-null model.

Figure 2

(A) Bar graph shows means ± SD of prostate weight of 1-year-old PB-Pten and PB-Pten-Rbpj mice. n = 3 per group. No significant difference is noted between the 2 groups (Student’s t test). (B) H&E staining of anterior (AP), dorsolateral (DLP), and ventral (VP) prostate tissues from 1-year-old PB-Pten and PB-Pten-Rbpj mice. (C–E) Coimmunostaining of K5 and K8, P63, and AR (C); Ki-67 and K8 (D); and cleaved caspase 3 (CC3) and K8 (E) of prostate tissues from 1-year-old PB-Pten and PB-Pten-Rbpj mice. Scale bars: 50 μm.